Cell Cover Today: What happens when a cell is infected with a new coronary virus?

Today, The Cell, a leading academic journal, presented a large-scale study of the new corona virus in the form of a cover paper.
a multinational team found that when cells become infected with the new coronary virus, there are many significant changes.
researchers also found that some drugs could target these changes, potentially treating new coronary virus infections. In their paper,
blue cell silky pseudo-foot protrusions with orange budding virus particles (Image credits: Elizabeth Fischer, NIAID/NIH) point out that as a new class of coronaviruses, the new coronavirus has an "asymptomatic infection" that can be contagious before symptoms appear.
't know enough about how the virus can change after infecting cells.
for this reason, the large team decided to use the mass spectrometry-based quantitative phosphoric acid proteomics method to study whether the phosphorylation process in cells is affected by infection with common cell lines.
phosphorylation is a key regulatory step of intracular signaling path.
to understand how proteins from hosts and viruses are phosphorylated after infection, hopefully allowing us to understand the pathology of the disease.
, as the researchers had expected, there was a significant increase in phosphorylation of many proteins at different points after the virus infected the cells.
this includes both proteins from the new crown virus and some host proteins that intergeneration with the new crown virus protein.
At different points after infection, the phosphorylation processes of different proteins vary and are related to the viral cell cycle (Image source: Resources 1) The researchers further divided them into five different groups based on the dynamics of these phosphorylation sites.
Interestingly, each group can be hooked up to the life cycle of the virus - the first group is up within 2 hours of infection and is related to the virus entering the cell; the second group is associated with replication and/or out-of-office (egress), the third and fourth groups are related to RNA processing and can be reduced, and the fifth group is associated with the response to infection.
, after infection with the new coronary virus, CK2 and p38 MAPK are activated, and a variety of cytokines are produced, eventually shutting down kinases associated with fission, causing the cell cycle to stop.
addition, CK2 also promotes cell production of filopodial protrusions, which carry budding virus particles.
moment was also recorded by scientists and featured on the cover of this issue of the magazine.
useful to understand these changes in phosphorylation in the illustration of this study (Picture Source: Resources) Based on changes in the activity of kinases responsible for phosphorylation and known drug actions, scientists have found 87 different drugs and compounds that promise to be potential new coronary virus infection drugs.
10 of the 87 molecules have been approved for listing by the FDA, and 53 are already in clinical trials.
researchers tested the antiviral activity of 68 drugs and compounds and identified strong antiviral potential for inhibitors such as CK2, p38 MAPK signaling path, PIKEYVE, and CDK, and are therefore expected to be potential targets for the future.
: s1. Mehdi Bouhaddou et al., (2020), The Global Making Landscape of SARS-CoV-2 Infection, Cell, DOI: