Cell Metabolism: Big Discoveries! Wang Daowen's team at Huazhong University of Science and Technology has revealed that insulin use can significantly increase mortality in new crown patients

COVID-19 caused by SARS-COV2 infection can lead to multiple organ damage and significant mortality in severe and critically ill patients, especially those with type 2 diabetes (T2D) complications.
active blood sugar control can reduce mortality, it is not clear whether treatment options, including insulin therapy, are beneficial for patients with COVID-19 and T2D.
November 23, 2020, the Wang Daowen team at Huahua University of Science and Technology published a research paper entitled "Insulin treatment is associated with increased mortality in patients with COVID-19" online, which surveyed 689 COVID-19 and T2D patients in a queue of 3,305 cases in Wuhan, China.
unexpectedly, the study found a significant increase in insulin therapy and mortality in patients with COVID-19 and T2D . . . 27.2% vs. 3.5%; adjusted HR, 5.38 (2.75-10.54).
further analysis showed that insulin therapy was associated with an increased systemic inflammatory response and an increase in important organ damage.
, care should be taken with insulin therapy in patients with COVID-19 and T2D.
, August 20, 2020, Wuhan University, Central South University, Central China University of Science and Technology, UCLA and other institutions to cooperate, Yuan Yufeng, Wei Xiang, Zhigang, Ji Yanxiao, Li Hongliang co-newsletter published online in Cell Metabolism entitled "Metin Use Is Is Associated with Increased Increased of Acidosis but Mortality and Individual coVI A retrospective study of 1,213 hospitalized COVID-19 and previously patients with T2D showed a significant correlation between metformin use and the rate of acidosis, especially in severe COVID-19 cases, but not 28 days of COVID-19-related mortality.
addition, metformin use was significantly associated with reducing heart failure and inflammation.
the study provides clinical evidence to support the continuation of metformin therapy in patients with COVID-19 and pre-existing T2D, acidosis and kidney function should be carefully monitored in patients with severe COVID-19 (click to read).
April 30, 2020, Wuhan University Li Hongliang, Huang Xiaodong, Zhang Pinghong and Guo Wei of Guangdong Pharmaceutical University published an online newsletter entitled "Association of Blood Glucose Control and Outcomes in Patients with CO A retrospective, multi-center study of 7,337 COVID-19 cases in Hubei Province, China, in which 952 cases already had T2D, was present.
the study is the first in the world to clearly demonstrate that good blood sugar control, i.e. maintaining a blood sugar variation range of 3.9-10.0 mmol/L, is closely related to a significant reduction in mortality in patients with neo-coronary pneumonia combined with diabetes (click to read).
the rapid increase in new cases, coronavirus disease (COVID-19) in 2019 quickly attracted global attention.
new coronavirus infection is believed to have been transmitted from animals and the pathogen has been identified as SARS-CoV-2.
until January 2020, it is suspected that the first infected patients were infected with the virus through human-to-human transmission.
since January 2020, the virus has spread rapidly to most of China and other countries.
the rapid increase in new cases, coronavirus disease (COVID-19) in 2019 quickly attracted global attention, with pathogens identified as SARS-CoV-2.
(November 26), according to real-time statistics released by Johns Hopkins University, there are more than 60.86 million confirmed cases of new crown pneumonia and 1.42 million deaths worldwide.
these figures are updated daily and are expected to increase further.
more than 460 million people with diabetes in the world.
recent studies have shown that individuals with diabetes have a higher risk of SARS-CoV-2 and have a lower prognosmation than those without diabetes.
a recent retrospective study of patients with COVID-19 and type 2 diabetes (T2D), patients with well-controlled blood sugar levels had a lower mortality rate than those with poor blood sugar levels.
article pattern map (pictured from Cell Metabolism), blood sugar control is also important for patients with COVID-19 and T2D, in addition to standard therapies, to reduce the risk of death and adverse consequences.
earlier studies suggested using insulin instead of oral anti-glycemic drugs to control blood sugar, clinical evidence suggests that insulin is beneficial in patients with COVID-19 and T2D.
study aims to assess the efficacy of different antidiabetic options based on clinical outcomes in patients with COVID-19 and T2D, and to provide clinical evidence to address whether insulin therapy is beneficial or harmful to these patients.
retrospective study looked at 689 COVID-19 and T2D patients in a queue of 3,305 people in Wuhan, China.
, the study found a significant correlation between insulin therapy and mortality in patients with COVID-19 and T2D . . . 27.2% vs. 3.5%; adjusted HR, 5.38 (2.75-10.54).
further analysis showed that insulin therapy was associated with an increased systemic inflammatory response and an increase in important organ damage.
, care should be taken with insulin therapy in patients with COVID-19 and T2D.
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