CELL MOL LIFE SCI Ji Xiong's research group reveals the functional mechanism of BRD2-mediated RNA polymerase II transcription

BRD2/3/4/T are members of the BET protein family in mammalian cells.

On June 4, 2022, Ji Xiong's group from the School of Life Sciences and the Life Center of Peking University published an online article entitled "BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation" in the journal Cellular and Molecular Life Sciences research paper

In this work, the authors first established an embryonic stem cell line that transiently degrades BRD2 protein.

Based on the above findings, the authors further explored the physiological significance of BRD2 regulation of Pol II transcription using mouse embryonic stem cell in vitro differentiation and multi-omics techniques

Figure 1.

Ji Xiong, a researcher from the School of Life Sciences and the Life Center of Peking University, and Huang Jie, a postdoctoral fellow, are the co-corresponding authors of the paper

Article link: https://link.