-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Iron is an essential element in the process of life, and it can combine with hemoglobin to transport oxygen.
At present, the clinical detection and diagnosis of iron overload are still insufficient, and the role of genetic factors in this process is unclear.
The international academic journal "Cell" published an online study titled "A role of PIEZO1 in iron metabolism in mice and humans" by the Ardem Patapoutian team of the Howard Hughes Institute of Medical Research in the United States.
Hereditary Xerocytosis (HX) is a rare disease caused by a gain-of-function (GOF) mutation in the PIEZO1 gene.
The researchers found that the dysregulation of macrophage-specific hepcidin is a key factor in the age-related iron overload of GOF PIEZO1 mice.
Data shows that African Americans have higher serum iron levels.
All in all, this study clarified the physiological relevance of iron mechanical transduction in rare HX patients and transgenic mouse models, determined the genetic risk factors for iron overload in the African population, and proposed new ideas and research for iron deficiency treatment direction.