Cell Rep: Causes of high-risk women with ovarian cancer

Stem cell scientists have revealed the origin of a common ovarian cancer by establishing a fallopian tube tissue model, allowing them to describe how genetic mutations put women at a high risk of this cancer

In the United States, ovarian cancer is the leading cause of death from gynecological cancer.

Faced with such a huge chance, some women with BRCA-1 gene mutations choose to have their breasts, ovaries and fallopian tubes removed by surgery, although they may never develop cancer in these tissues

Dr.

Svensson is a professor of biomedical sciences and medicine, and one of the corresponding authors of this new study in Cedars-Sinai

To achieve this discovery, the research team created induced pluripotent stem cells (IPSCs) that can produce any type of cell

Dr.

Svensson said that in addition to showing how the fallopian tubes of women with breast cancer susceptibility gene (BRCA-1) mutations "bred" ovarian cancer, this organoid technique may also be used to determine whether drugs work on individuals

"This research represents an exciting application of IPSCs, bringing us closer than ever to significantly improving outcomes for women with this common ovarian cancer," said Jeffrey Golden, MD, a research and graduate student Deputy Director of Education and Director of Cedars-Sinai Burns and Allen Institute

Article title

Human ipsc-derived fallopian tube organoids Overview of early carcinogenesis in BRCA1 mutation carriers