Cell Rep: The Gospel of Women! Scientists have discovered the "secret" of childbirth, which may not be painful in the future.

!---- is generally the most painful child when the majority of women have childrenIf classified according to the 12 thalbs of pain circulating on the Internet, the severe pain of being beaten with a stick is 7, and the pain of a pregnant woman in childbirth can reach the top levelWhy do women have such a strong sense of pain when they give birth? This is mainly related to uterine contraction and cervical expansion during the first birthHowever, some women don't seem to feel as much pain when they have childrenIt is reported that this may be related to the amount of activity of pregnant women, usually a large amount of pregnant women, the production process is relatively smooth and pain will be reduced accordingly, while the amount of activity of pregnant women, may be due to extreme tension and fear to increase the painResearchers at the University of Cambridge recently investigated why some women experience pain reduction during and after childbirth, in the journal Cell ReportsThe researchers found that there was a genetic variant that naturally relieves pain (KCNG4/KV6.4- KV6.4-Met419), which about 1 in 100 women carry, which they believe reduces the pain signals that nerve cells send to the brainThere is some connection between genetic variation and pain perceptionGenes can affect the secretion of proteins, and some proteins can regulate cell sites, neuronal excitability, and specific voltage-gated ion channels (Kvvs) of the nociceptor, which affect pain thresholdsSimply put, this protein acts as a "door" and can be regulated by the electrical signal to the sensitivity of pain perceptionThe researchers extracted DNA from 10mL blood or 2mL saliva in 158 women who gave birth with pain insensitive labor and performed molecular genetic analysis of these gene queues, and found that the KCNG4 gene in these women generally carried too much single nucleotide polymorphism allele gene (SNP) rs140124801In addition, the researchers found that the high expression of rs140124801 causes a gene mutation (KCNG4-KV6.4-Met419), which may hinder the conduction path of the K-ion, which affects the excitability of neurons, meaning that the variation of the KCNG4 gene may make people less sensitive to painTo learn more about how this genetic variant reduces pain, the researchers studied the expression of KCNG4 and KCNB1 in sensory neurons in the womb in mice and found that the gene variant caused loss of regulation function of KV2.1, a major component of delayed potassium rectifier current in neurons, and reduced the excitability of sensory back-root nerve knot (DRG) neuronsAs a result, the researchers speculated that the path of pain signaling in the womb of women carrying the rare KCNG4 SNP rs140124801 might be "cut off" without feeling severe pain during childbirthEwan StJohn Smith, senior author of the report and head of the team at the Department of Pharmacology, concluded, "We found that genetic mutations in women who reduce pain during childbirth lead to cell cell transformation" defects that reduce the likelihood of pain signals reaching the brain"Overall, this study is undoubtedly a boon for women in general and promises to significantly reduce or even eliminate the severe pain they experience during childbirth!" At the same time, in some extreme pain, the use of the application value of this study can be used to develop "painless" drugs, which will be a boon for pain-sensitive people!