Cell Reports: After a severe seizure, microglia not only remove debris, but also heal damaged dendrites

Common epilepsy prevention drugs are ineffective for about one-third of epilepsy patients, so new treatments for this type of brain injury are very much in need .

Common epilepsy prevention drugs are ineffective for about one-third of epilepsy patients, so new treatments for this type of brain injury are very much in need .

Immunity contributes to the development and stability of neuronal structure and functional networks

After a severe seizure, a severe seizure induces the formation of a pocket of microglia, and the microglia heals the damaged dendrites through physical interaction with the dendrites of neurons

In this study , the researchers used the advanced imaging technology of the two-photon microscope to examine what happened in the brain of laboratory mice after severe seizures

In this study , the researchers used the advanced imaging technology of the two-photon microscope to examine what happened in the brain of laboratory mice after severe seizures

Real-time dynamic changes of the microglia process bag caused by epileptic seizures

Real-time dynamic changes of the microglia process bag caused by epileptic seizures

These strange little bags-scientists named them "little gummy process bags"-stayed there for several hours

These strange little bags-scientists named them "little gummy process bags"-stayed there for several hours

The researchers recorded a microglial cell phenotype, and called it the microglial cell process pocket or MPP, which was strongly induced after a severe seizure, wrapped around the beaded dendrites, and maintained stable for several hours.

References : Ukpong Eyo B.
et Al, microglia Resolution to Provide Structural injured dendrites After Severe seizures, the Cell Reports the Cell Reports(2021).
The DOI: 10.
1016 / j.
celrep.
2021.
109080 the DOI: 10.
1016 / j.
celrep.
2021.
109080 in this message