Cell Reports Yu Faxing's group reports on Hippo pathway cell surface regulatory elements and tumor targeted therapy strategies

Hippo signaling pathway plays an important role in tumorigenesis and development, and its effector protein YAP/TAZ transcription cofactor is significantly activated in a variety of tumors [1,2]

On August 30, 2022, Faxing Yu's group from the Institute of Biomedical Sciences, Fudan University published a long article in Cell Reports entitled Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers research paper

This study firstly screened 16 potential Hippo pathway regulatory elements with clinical significance by integrating TCGA clinical data with the binding proteomic data of the main elements of the Hippo pathway, and identified KIRREL1 as a negative regulator of YAP/TAZ activity

KIRREL1 is a transmembrane protein, and the immunofluorescence experiments in this study also confirmed that both KIRREL1 and p35 KIRREL1 are localized to the cell membrane

It is worth mentioning that the Feng Cong team of Novartis and the Junjie Chen team of MD Anderson Cancer Center reported in Nature Communications and Proc Natl Acad Sci USA, respectively, that KIRREL1 is a new regulatory element upstream of the Hippo pathway [4,5]

Gu Yuan, an eight-year doctoral student at Fudan University's 2015 Clinical School of Medicine, is the first author of this paper, and researcher Yu Faxing is the corresponding author

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Faxing's research group has long studied the regulation mechanism and function of Hippo signaling pathway (development and tumor), and recently published papers in journals such as Cell, Molecular Cell, Cell Research, Cell Reports, Protein & Cell, EMBO Reports, etc.