Cell Stem Cell: A mouse embryonic model derived from stem cells

The new study was published Sept.

Zernicka-Goetz, professor of mammalian development and stem cell biology in The University of Cambridge's Department of Humanities, Development and Neuroscience, said: "This discovery opens up new avenues for understanding why most human pregnancies fail and creates knowledge

"As we further develop these models, we will learn more about the signals that initiate and guide organ development, which will provide us with pathways to help grow organs, and ultimately find applications in transplant surgery or regenerative medicine," she explains

In a paper published in the journal Nature on the 25th, the research group detailed the method

Naturally, in the first few days after fertilization, three main tissues develop in the mouse early embryos: one eventually becomes body tissue, and the other two support the embryo's development

Three types of stem cells were extracted from these three tissues of mouse embryos and cultured

Building on previous research, the mouse embryonic model reported in the new paper consists of only a single cultured stem cell: embryonic stem cells (ESCs

Zernicka-Goetz explains: "Of these three stem cell types, only ESCs are pluripotent – that is, only ESCs have the potential

Journal Reference:

1. Kasey Y.