Cell Stem Cell: Accident! Free fundamentals are good for the brain and can promote the production of new nerve cells by neural stem cells

December 8, 2020 // --- active oxygen molecules, also known as "free agents," are often considered harmful.
, however, they now turn out to control cellular processes that are important for the brain's ability to adapt, at least in mice.
researchers from the German Center for Neurodegenerative Diseases (DZNE) and the University of Dresden's Center for Regenerative Therapy (CRTD) published their findings online December 3, 2020 in the journal Cell Stem Cell under the title "ROS Dynamics Delineate Functional States of Hippocampal Neural Stem cells and Their To Their-Dependent Exit Quiescence."
from Cell Stem Cell, 2020, doi:10.1016/j.stem.2020.10.019.
the authors focused on the "sea mass," a brain region that is thought to be the control center for learning and memory.
new nerve cells are produced through their lifetimes, even in adulthood.
Kempermann, co-author of the paper and head of the CRTD research team, explains, "This so-called adult neurogenesis helps the brain adapt and change over its lifetime.
it happens not only in mice, but also in humans.
nerve cells produced from stem cells as triggers for the "ocular" nerve.
, "These stem cells are an important basis for neuroplasticity, which we call the brain's adaptability," said Professor Kempermann.
, he and his colleagues have a new understanding of the formation of new nerve cells.
team was able to confirm in mice that neural stem cells contained large amounts of free fundamentals compared to adult nerve cells.
especially when neural stem cells are dormant, which means they don't divide, they don't divide into nerve cells," he said.
new study shows that increased concentrations of free fundamentals prepare neural stem cells for division.
" free fundamentals act like a switch that lets nerves start.
" free fundamentals are normally metabolized waste.
cellular mechanisms usually ensure that they do not accumulate.
this is because reactive oxygen molecules cause oxidative stress.
Kempermann explains, "It is well known that excessive oxidative stress is detrimental.
can cause nerve damage and trigger the aging process.
, but obviously that's just one aspect, and there's a good side to freekids.
also show signs of this in other cases.
, however, it is surprising that neural stem cells in our brains not only withstand such high levels of freegen, but also use them to function.
", also known as antioxidants, can counteract oxidative stress.
, such substances are considered an important part of a healthy diet.
they can be found in fruits and vegetables.
the positive effects of antioxidants have been proven, and our study does not question this," kempermann, a researcher at the University of New China, stressed.
we should also be careful to draw conclusions for humans based on purely laboratory research.
, however, our results at least show that free radicals are fundamentally not bad for the brain.
fact, they are likely to be important for the brain to remain adaptable through its lifetime and age in a healthy way.
" (Bioon.com) Reference: 1. Vijay S. Adusumilli et al. ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence. Cell Stem Cell, 2020, doi:10.1016/j.stem.2020.10.019.2.Free radicals good for the brain: New insights into the mechanisms of neuroplasticity。