Cell Sub-Journal . . . Chinese scholars have found heavy evidence that the new coronavirus is not a laboratory leak, but a natural evolution.

Novel coronavirus pneumonia (novel coronavirus) has been debated by politicians and the public for the world. COVID-19 has been the source of new coronavirus.although researchers believe novel coronavirus is the natural host of bat, the final origin of the virus is not yet fully established.recently, the team of Shi Weifeng of Shandong First Medical University published a research paper entitled "a new bat coronavirus closed related to sars-cov-2 contains natural insertions at the S1 / S2 clearance site of the spike protein in the journal Current Biology.the team described a recently discovered bat coronavirus named rmyn02. The novel coronavirus has been closely related toin some regions of genome.similar to the new coronavirus (sars-cov-2), rmyn02 has several amino acids inserted at the junction of S1 and S2 subunits of the spike protein (s protein). Although novel coronavirus is not the direct ancestor of RmYN02,'s findings suggest that these seemingly unusual insertions can actually occur naturally during the evolution of coronavirus, according toresearchers. The novel coronavirus, Professor Shi Weifeng, director of the Institute of pathogen biology, Shandong First Medical University, said that since the discovery of the new coronavirus, many unfounded claims that the virus originated in the laboratory, especially that the insertion of S1 /S2 amino acids into the new crown virus is unusual, probably due to laboratory manipulation.and this latest study by Professor Shi Weifeng's team clearly shows that these evolutionary events can occur naturally in wild animals.this provides strong evidence that the new coronavirus (sars-cov-2) is not a laboratory leak.the team identified the coronavirus rmyn02 from 227 bat samples collected in Yunnan Province of China from May to October 2019.since bat was found to be the natural host of SARS coronavirus in 2005, there has been a great interest in bat as a natural host of infectious diseases, especially because bats carry highly diverse RNA viruses, including coronavirus. Shortly after the novel coronavirus was discovered and identified in early January2020, the RNA of these batches was sent to the genome for high-throughput sequencing. The novel coronavirus, the closest to thegenome, is another virus named RaTG13, which was found in bats in Yunnan province.novel coronavirus novel coronavirus is more closely related to the newly discovered RmYN02 in some regions of the genome. The region includes the longest encoding region 1ab of the new coronavirus genome, with a similarity of two between the 97.2% sequences.new coronavirus (sars-cov-2) infects host cells by binding to human ACE2 via the spinin receptor binding domain.and RmYN02 encoding novel coronavirus sequences are less similar to the new cov genome, which means that it is unlikely to infect human cells. the key similarity between new coronavirus (sars-cov-2) and rmyn02 is that rmyn02 also has amino acid insertion at the junction of two subunits of its spike protein. a significant feature of new coronavirus (sars-cov-2) is the insertion of four amino acids at the junction of S1 and S2. is a novel coronavirus, and has been found in all new coronavirus sequences so far. although novel coronavirus is different from RmYN02, it indicates that similar amino acid insertion events can occur independently. moreover, the occurrence of similar insertion events in a virus found in bats strongly proves that such insertions are of natural origin. the results of this study suggest that these seemingly unusual insertions can actually occur naturally in animal derived beta coronavirus. "Novel coronavirus is more novel coronavirus," professor Shi Weifeng said. "This study provides more clues for revealing the origin of the new coronavirus, but neither RaTG13 nor RmYN02 is the direct ancestor of the new crown virus (SARS-CoV-2), because the two viruses are still far from the new coronavirus in evolution. Novel coronavirus, novel coronavirus, is a new form of coronavirus. , but this study shows that collecting more wild animal samples will help reveal the virus that is more closely related to the new coronavirus and even its immediate ancestors. This will tell us how the new coronavirus appeared in nature. it is reported that this work has won the academic promotion plan of Shandong First Medical University, the strategic key research plan of Chinese Academy of Sciences, the National Natural Science Foundation of China, the national science and technology major special project, the Yunnan Provincial high-end foreign experts program, the Shandong Taishan Scholars Program, the National Natural Science Foundation for outstanding young scientists, the youth innovation promotion association of Chinese Academy of Sciences, and Australia Sub arc winner fund support. paper links: