Cell sub-journal: Obesity can damage memory through bacteria.

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human studies have shown that the membership and function of specific intestinal bacteria are associated with memory ability and volumeof specific brain regions;
some thick-walled bacteria and mycobacterium/deformation bacteria members, respectively, are positive and negatively related to memory ability, aromatic amino acid (AAA) metabolism and carbon metabolism and other related bacterial functions are also associated withmemory; 3.
levels of AAA and its decomposing metabolites, as well as beet alkalis in plasma and feces, were associated with memory4.
obesity affects these relationships and is associated with memory ; 5.
transplanting obese populations reduced memory scores in the recipient mice, who had short-term memory associated with the brain's AAA pathway, inflammatory gene expression, and specific gut bacteria.. A recent studytherecommended by ,Mildbreeze suggests that learning and memory are associated with gut microbiotics and their metabolites. A new study published by Cell Metabolism explores the relationship between intestinal bacteria and memory function, as well as the effects of obesity, suggesting that the metabolic effects of gut microbiota on aromatic amino acids may have important effects on memory function.. Cell Metabolism(IF:21.567) Obesity Impairs Short-Term and Working Memory Via Gut Microbial Metabolism of Aromatic Amino AcidsObesity through aromatic amino acids in the gut microbiome metabolism, damage to short-term and workingmemory 10.1016/j.cmet.2020.09.002
10-06, Article Abstract: The gut microbiome has been linked to fear of learning in animal models. Here, we aimed to explore the gut microbiome and memory domains according to to obesity status. A specific microbiome profile associated with short-term memory, working memory, and the volume of the hippocampus and frontal regions of the brain differentially in human subjects with and without obesity. Plasma and fecal levels of aromatic amino acids, their catabolites, and vegetable-derived compounds were longitudinally associated with short-term and working memory. Functionally, microbiotacareation from human subjects with obesity led to deled memory scores in mice, aligning this trait from humans with that of recipient mice. RNA sequencing of the medial prefrontal cortex of mice revealed that short-term memory associated with aromatic amino acid pathways, an industry genes, and clusters of the species. Theses results highlights the potential therapeutic value of targeting the gut microbiota for memory means, specifically in subjects with obesity.
First Authors:
. Maria Arnoriaga Rodríguez, Jordi Mayneris-Perxachs
Correspondence Authors:
Rafael Maldonado, Jose Manuel Fernández-Real
All Authors:
Maria Arnagaori Rodriguez, Jordi Mayneris-Jordi Mayneris-Perxachs, Aurelijus Burokas, Oren Contreras-Rodriguez, Gerard Blasco, Clíudia Coll, Carles Biarnés, Romina Miranda-Olivos, Jèsica Latorre, José-Maria-Moreno-Navarrete, Anna Castells-Nobau, M?nica Sabater, María Encarnación Palomo-Buitrago, Josep Puig, Salvador Pedraza, Jordi Gich, Vicente Pérez-Brocal, Wifredo Ricart, Andres Moya, Xavier Fernández-Real, Lluís Ramió-Torrent, Reinald Pamplona, Joaquim Sol, Mariona Jové, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernández-Real
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