Cell: the study of vesicles is helpful for the innovative treatment of degenerative diseases

Marina gomzikova, research leader of the gene and cell technology lab, started working on ecmvs in 2013, when she was studying for her Ph.D Since then, the cells derived from human mesenchymal stem cells (MSCs) have been found to have very promising properties Ecmvs are microstructure surrounded by plasma membrane, which have been proved to be a promising therapeutic tool due to their biocompatibility, miniaturization, safety and regeneration Microbubbles can be used to bypass the existing limitations of cell therapy without losing efficacy At the Federal University of Kazan, researchers are studying cytochalasin B-induced vesicles (cimvs) They are derived from mesenchymal stem cells and are very similar to ecmvs Image source: cell A new study has studied and characterized the biological activity of cimvs derived from MSC Many bioactive molecules, such as growth factors, cytokines and chemokines, were found in cimvs, and their immunophenotypes were described Most importantly, researchers have found that cimvs stimulate angiogenesis, the growth of blood vessels, just like stem cells Therefore, the team believes that human cimvs MSCs can be used for cell-free treatment of degenerative diseases Cimvs MSCs can induce therapeutic angiogenesis in the treatment of ischemic tissue injury (e.g., ischemic heart disease, hindlimb ischemia, diabetic angiopathy, and nutritional ulcer), in the case of skin injury, stimulation of regeneration (trauma and burns), neurodegeneration (multiple sclerosis and Alzheimer's disease), or traumatic injury (peripheral nerve injury and spinal cord injury) Required process Gomzikova's team will continue to explore the potential of artificial microbubbles in the treatment of autoimmune diseases They are also interesting in the use of carrier properties (i.e., the ability of the vesicles to deliver) in the treatment of tumors In conclusion, cimvs can be a new therapeutic tool and a new class of effective and safe drugs for regenerative medicine (BIOON Com) reference material: