Cell: Zhang Chunli's research team reveals that strict lineage tracing is critical to the study of nerve cell regeneration

Through rigorous lineage tracking, researchers at UT Southwestern showed that putative astrocyte-transformed neurons are actually endogenous neurons

Scientists at the University of Texas Southwestern Medical Center (UT Southwestern) have discovered that strict lineage tracing is critical to the study of nerve cell regeneration

Lineage tracing is a basic method in developmental biology, which refers to a test used to map the progeny of a specific cell in an organism

Lineage tracking is also the core of the field of stem cell biology.

Carolina Serrano Garcia, Zhang Chunli and Wang Leilei

Dr.

After dozens of experiments using a series of protocols, the researchers determined which specific pedigree tracking analysis is the most robust and reliable, the so-called gold standard test

At the end of the study, reliable pedigree tracing tests are listed, and it is strongly recommended that these tests be used in all laboratories engaged in nerve cell regeneration research

Dr.

In UT Southwestern, Dr.

Through rigorous lineage tracking, Dr.

Earlier this year, they reported in the journal Cell Stem Cell that after spinal cord injury in mice, the potential neurogenesis of glial cells can be used to generate new neurons and lead to functional recovery

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Revisiting astrocyte to neuron conversion with lineage tracing in vivo

DOI: https://doi.