Cell: Zhejiang University found that the high-potassium environment in tumors can reshape tumor-associated macrophages

As a unique niche, the steady-state of tumor microenvironment (TME) is regulated

On September 13, 2022, Professor Wang Di of the School of Basic Medicine of Zhejiang University and the team of Professor Ding Kefeng of the Second Affiliated Hospital of Zhejiang University School of Medicine published a research paper

Tumor-associated macrophages (TAMs) are a dynamic and highly heterogeneous cell population within tumors whose heterogeneity reflects their dual role in tumor progression and clinical prognosis: they can not only play a tumor-killing function and induce anti-tumor responses, but also promote tumor immune escape and immune resistance

Using a variety of mouse tumor models as well as human clinical tumor samples, the researchers found that high K+ in tumors showed inhibitory effects

In the study of the mechanism, the researchers found that Kir2.

To further explore the association of Kir2.

Finally, the authors used the selective inhibitor ML133, a selective inhibitor of Kir2.

In summary, this study identifies Kir2.

Professor Wang Di of the Department of Immunology, School of Basic Medicine, Zhejiang University, and Professor Ding Kefeng of the Department of Colon Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine are the corresponding authors of this paper, and Chen Sheng and Dr.

Professor Wang Di's team has long been engaged in the study of immune metabolism and metabolic communication between different types of cells in the tumor microenvironment and damage repair process, and the research group has long been recruiting postdocs with good academic background and experience in biotrust analysis to join, interested parties should contact diwang@zju.