Ceres Research Institute: NR, NMN, NADH and other complementary anti-decay factor NAD plus substances what is the difference?

NAD plus full name niacin adenine dinucleotide, is a coenzyme in the body, is said to be closely related to aging.
because scientists have found that animals such as mice and beautiful cryptobacteria have decreased in body NAD-plus levels as they age, similar findings have been made in human trials.
they thought that raising NAD-plus levels might fight aging.
, we often say what's missing to make up for it, and it doesn't work here at NAD plus.
studies have shown that direct supplementation with NAD plus does not relieve the symptoms of aging.
can't be absorbed and utilized by cells because of direct supplementation of NAD plus.
, the researchers were able to find only one indirect way to raise the level of NAD-plus.
, supplements associated with prebiotic NMN, pre-prebiotic NR, reduced-state NADH, etc. began to take the lead.
these NAD-plus supplements have been hailed as "anti-decay drugs" since their inception, because many in the business world have come to terms with good results and are sought after by many.
NR, NMN, NADH are the current three main ways to supplement NAD plus, today we have to sort out the same can supplement NAD plus, what is the difference between them? Root Zhengmiao Red NMN NMN is an abbreviation for niacin mononucleotides, which has been applied for 6 years.
a 2013 experiment by Harvard University's Paul F. Glenn Center for the Biology of Aging, NMN was able to extend mammalian life expectancy by more than 30 percent.
Professor David Sinclair of Harvard Medical School and his team found that when the supplemented NMN enters the cell and consumes an ATP, it forms a NAD-plus molecule, which effectively increases the amount of NAD-plus in the body, helping humans repair DNA damage and delay aging.
In 2016, a team led by Japanese professor Ichiro Ioi of the University of Washington published the latest NMN research in the American scientific journal Cell Metabolism, whose anti-aging effects have been confirmed and are beginning to be used in humans, which has been in use for three years.
Ichiro Ishii, University of Washington, USA, presents the results of the NMN experiment in cell, a top academic journal, in 2018, proving once again the anti-decay function of NMN.
said in an interview that he himself takes 1,000mg of NMN every day and that his family is eating and feels much younger.
NMN was immediately the major media and research institutions as "long-term medicine" title.
, Professor David Sinclair was named "the 100 most influential people in the world" by Time magazine.
NMN has since become the darling of the anti-aging world.
NMN this product is relatively easy to produce, so every month there are a large number of new brands into the market, but the quality is uneven, more representative brands include Gene Harbor, Revito, Serifu and so on.
NMN fire, can not be separated from commercial speculation, we can see on the Internet every day a lot of big guy celebrities and NMN related, but there is no proof, most of Zhang Guan Li Dai.
buffett, who is often hyped, said he had invested heavily in NMN without any strong evidence to prove it.
li Ka-shing, Pan Shiyi and other business tycoons eat not NMN at all.
Although these are hype, but in marketing is undoubtedly very useful, the future may also appear a lot of "Buffetts", which makes the author inexply some worry, this is a good thing, will not be this kind of mixed publicity of the fish and dragons do not know what to believe? Although NMN is currently very hot, but because a variety of untested products have poured into the market, the industry began to worry about its security issues (Tencent's more true column has sent a more true identification of NMN), but so far has not found strong evidence that it has some kind of risk, so some responsible businesses in order to ensure its security and do something.
of the three representative NMN products, Gene Harbor, Revito and Seilvifu, gene harbor and Seilvifu are available in official channels, except that revitaltation of safety can not be found.
E.e. Gene Harbor shows the U.S. FDA standard GRAS certification, because the U.S. FDA for NMN products such as the after-the-fact filing system, and will not be certified in the early stage, and this certificate is marked as "self-certification", so this certificate is often criticized, but can not deny that the business wants to prove product safety of the original intention.
self-certification is the loosest of the three forms of GRAS certification, in the form of a panel of experts to defend themselves if someone challenges it. screenshots of
Gene Hong Kong JD.com's overseas flagship store Another Sai Lifu shows a long-term safety test conducted by the Zhejiang Academy of Medical Sciences in 2016, which was conducted for eight months from multiple levels, including cells and genes (the eight-month safety test was a high standard, according to industry insiders).
test report shows that the report was obtained in 2017, when NMN has not yet entered China, through the investigation to understand that the earliest time to go on sale in China is August 2019, during which manufacturers are not because of safety concerns and did not launch early we do not know, but as far as the current market is concerned about the gold content of this report is still relatively high.
Sai Li Fu Jingdong overseas flagship store screenshot NMN has been praised as the best way to supplement NAD plus because it is a direct prelude to NAD plus, but in fact, because NMN needs the help of enzyme NMNAT in the conversion process, but also need to consume ATP, so the conversion rate is limited, scientists are currently studying ways to improve conversion efficiency or develop more efficient similars.
celebrity holding NR NR is an acronym for niacin rnacogen, it is a prelude to NMN, into the body needs to be converted into NMN and then converted to NAD,, the action of the system and NMN is basically the same, but because of the need for multiple conversions, so the conversion efficiency is lower than NMN.
NR enters the human body and needs NPK1 to 2 phosphate to become NMN, while the mitochondrial body does not have NPK1 and NPK2 enzymes to convert NR to NMN.
, most of the NR is not converted to NMN, but is digested into niacin (NAM).
most of the oral NR in the body is digested into NAM, still can not change the remedy synthesis pathway speed limit enzyme NAMCT limit limit, so the ability to supplement NAD plus is limited.
as early as 2004, studies have shown that NR can reduce age-related functional decline in various mouse models, and its applied research history has been 15 years.
but in fact the NR's real human time has been around since 2012, about seven years old, and there have been four published human safety experiments.
NMN is applied before the NMN but not as famous as NMN, probably because of the limitations of absorption rate.
representative brands include Tru Niagen of ChromaDex and Basis of Elysium.
What really made NR famous was two celebrity events: one was in 2017, when Hong Kong's richest man, Li Ka-shing, invested $25 million in Tru Niagen of Chrome Dex, known in Hong Kong as "Legahin", and now the concept of online stealth is called NMN, but it's not.
"celebrity effect" bar, really let the NR fire, but the results do not seem very optimistic, there are media reports that ChromeDex in the second quarter of 2019 net loss of $7.755 million, it shows that the product is not popular.
another is earlier this year, SOHO China chairman Pan Shiyi posted a tweet, "I never believed in health care products."
a month ago, a professor at the Massachusetts Institute of Technology recommended a 'long-born sendan' from their school that had not yet been released.
asked him how he felt after eating.
he said, his nails grow faster after eating.
I ate for nearly a month, didn't react, and found my nails growing fast.
" is a health care product made by an American company called Elysium, which is rumored to be NMN, but also NR.
the addition of two big men to make NR shine, attracted attention.
But in addition to the low conversion rate, NR also has a fatal weakness is that it is not biosynthetic, can only be chemically synthesized, the production process needs to add chlorine elements to ensure its stability, so that synthetic NR is no longer a natural NR in the human body, so there may be unknown security risks.
there have been reports of side effects such as vascular dilation and redness of the skin from oral NR.
is probably innitably inadequate, so NR as a way to supplement NAD plus has been edwined.
high-efficiency NADH NADH is also the prototype niacin adenine dinucleotide abbreviation, is the reduced state of NAD.
the U.S. WebMD website, an internationally authoritative medical health information platform, describes NADH as niacin adenine dinucleotides (NAD plus) and hydrogen (H).
NADH can break down quickly into NAD plus when it enters the body, unlike NMN and NR, NADH is a decomposition reaction, which is much easier, and NMN and NR are more difficult to synthesize NAD plus.
because NADH is very easy to decompose, the efficiency of converting to NAD plus is the highest in the NAD plus family.
's applied research on NADH has been going on since 1987, and it's been more than 30 years since the human body took it, according to the data contained in the FDA Adverse Event Reporting System (FDA Adverse Event Reporting System) and years of user feedback, there have been no side effects reports, there have been more than 20 published human safety experiments, but why are NR and NADHMN on the market being hyped, brands constantly emerging, and NADHMN has not been heavily involved? In fact, Cheng also Xiao He lost Xiao He, the root cause is still the stability of NADH is difficult to solve.
Abroad, NADH has been the first to be used to treat a variety of diseases, but because it is very unstable, easy to degrade, can only be used now, and directly through intravenous use, this method is difficult to promote, difficult to produce applications, so it has become a difficult problem for scientists to overcome.
(FDA's description of NADH instability) Most of the NADH products currently on the market are sub-tongue tablets, long-term stability and effectiveness are questionable, and whether there is a safety risk associated with taking these tablets under the tongue has been controversial.
It is understood that the first to overcome stability problems, really can do long-term stability is also mentioned above, it uses a special process called Turn-A delivery system, to ensure the long-term stability and efficient absorption of NADH.
it is worth mentioning that Ceres NADH has been certified as an NPN in Canada (relevant information is available at the Ministry of Health on canada's official website).
mention this NPN certification is to say that countries' health care products regulatory system in fact uneven standards, but also an IQ tax "heavy disaster area."
According to existing national regulations on health care products, Canada is one of the world's most stringent regulations on health care products, a product to be marketed, Health Canada will conduct a rigorous review of the product formulation, to ensure that the ingredients in the statutory natural health product catalog, the use of raw materials in the human safety range, and the use of raw materials will not interact with human safety risks, after a year or so of approval time to grant NPN certificate, can be listed.
In this regard, the FDA is only an after-the-fact filing system, and Japan is polarized, only for specific health food strict supervision, most products can be easily marketed and sold, both countries are far less than Canada, so can obtain NPN certificate, security gold content is still very high.
need to emphasize that in terms of existing domestic and foreign markets, including NMN products, there are very few people who can get this NPN certificate.
fact, NMN is unable to obtain NPN certification because it is not included in Canada's list of statutory raw materials for natural health products, so it can be seen that the safety of NMN is officially recognized or a long way to go.
are talking about anti-aging, but really want to be more reliable, certainly can not bypass the aging of the rationale research.
2019's latest aging biology textbook, Biochemistry and Cell Biology of Ageing, summarizes decades of aging research, attributing the aging process to oxidative free-to-air damage and a decline in NAD-plus levels.
NADH can be efficiently broken down into NAD plus and hydrogen when it enters the body, which not only increases NAD plus levels, hydrogen is also the ideal substance for the efficient removal of free fundamentals, it seems that NADH also solves two of the most central problems related to aging.
, NADH will occupy an important position in the future anti-decay market.
wish to live long, has haunted people's minds since ancient times.
, such as Qin Huang Hanwu, also paid a lot of "IQ tax" for this matter.
there are also people who suspect that NAD plus is another IQ tax for those who want to pursue longevity resistance, but after analysis, it is found that the NAD plus family, although the advantages and disadvantages are clear, but still a material.
So we should be strict and open to new things, neither blindly follow the trend, nor blindly deny that many people may not live the year if the early developers of vaccines and antibiotics are also at their feet.
medical developments over the past two centuries have taught us that humanity has the power to defeat and to cause us pain.