Characteristics and technology of four common solid dosage forms, such as capsule and tablet

[technical article of pharmaceutical Station] pharmaceutical dosage forms can be divided into liquid, gas, solid and semi-solid according to different forms Among them, powder, granule, capsule and tablet are common solid dosage forms This paper mainly introduces the characteristics and process of these common solid dosage forms Powder refers to a powder preparation made of one or more drugs, which can be taken internally or externally The general process of powder preparation includes material pretreatment, crushing, screening, mixing, dosage, quality inspection, packaging and storage Among them, material pretreatment refers to the treatment of materials to the extent that they meet the requirements of crushing In the process of crushing and sieving, the raw and auxiliary materials for the preparation of powder shall be crushed unless they have met the requirements In the process of packaging and storage, the industry said that the focus of the packaging and storage of the powder is moisture-proof, because the dispersity of the powder is large, its hygroscopicity and weathering are significant In the process of quality inspection, it is necessary to check the uniformity, moisture content and the difference of loading capacity Granule is a kind of dry granule preparation with certain particle size which is made of medicine and appropriate auxiliary materials The utility model has the advantages of direct swallowing or flushing for drinking, convenient carrying, fast dissolution and absorption According to the industry, granules are generally prepared by the main steps of wet granulation, including crushing, screening, mixing, soft material preparation, granulation, drying, whole granule, grading or coating, dosage and packaging Among them, soft material manufacturing refers to fully mixing drugs with appropriate diluents and disintegrants, adding water or other adhesives to make soft material Wet particles are made by squeezing soft materials through the screen manually or mechanically Commonly used drying methods include box drying, fluidized bed drying and so on In the whole and grading process, the method of sieving is generally adopted In the coating process, the purpose is to achieve taste correction, meaning correction, stability, slow-release, controlled-release or enteric dissolution, etc the granules can be coated, generally commonly used film coating Attention should be paid to the uniformity of stored granules It should be sealed and stored in a dry place to prevent deterioration The quality inspection of granules should be carried out from the aspects of appearance, particle size, loss on drying, and difference of soluble loading Capsule includes hard capsule and soft capsule Among them, the hard capsule refers to the solid preparation made by filling the medicine in the hollow hard capsule or sealing it in the elastic soft capsule Hard capsule can mask the smell and taste of drugs, improve the stability of drugs and protect the efficacy of drugs Capsule coating can also achieve the purpose of targeted release The production of hard capsule can be divided into two aspects: the preparation of capsule shell and the filling of medicine The technological process includes crushing, screening, mixing, capsule filling, capsule dust cleaning, inspection and packaging The quality inspection includes appearance, moisture, difference of loading capacity, disintegration and dissolution, packaging and storage Compared with hard capsule, soft capsule has the advantages of strong plasticity and elasticity Tablet refers to the solid preparation in the form of round or heterogeneous sheet formed by the preparation technology after the drug and the appropriate auxiliary materials are evenly mixed The tablet can meet the requirements of medical and preventive medicine, with accurate dosage, convenient use, small volume and convenient carrying The tablet production needs to use tablet press equipment for tablet processing, and also need to use coating machine for coating, and complete the packaging of drugs.