Acute Lymphoblastic Leukemia (ALL) is the most common type of cancer in children and adolescents.
As early as 2014 Shanghai Children's Medical Center and St.
Committee member July 22, 2021, National Children's Medical Center (Shanghai)/Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Zhou Binbing, Key Laboratory of Children's Hematological Tumors, National Health Commission The team, the Jinghui Zhang team of the St.
The study comprehensively analyzed samples of 1951 ALL patients from China, the United States, and Germany, and found that the tumor suppressor gene TP53 R248Q mutation was significantly enriched in relapsed ALL
The results of this study provide experimental evidence that chemotherapeutics may directly induce drug-resistant mutations
author information
author information Assistant researcher Dr.
The research was co-funded by the National Natural Science Foundation of China, the Key Research and Development Program of the Ministry of Science and Technology, the German Children's Cancer Foundation, and ALSAC, a fund-raising and advocacy organization for St.
Related paper information: https://doi.
https://doi.
org/10.
1038/s43018-021-00230-8
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