Chen Yihua's research group from the Institute of Microbiology, Chinese Academy of Sciences published a review on heptose-containing microbial natural product drugs in NPR

Original title: Chen Yihua's research group from Institute of Microbiology, Chinese Academy of Sciences published a review on heptose-containing microbial natural product drugs in NPR

Sugar plays a pivotal role in life activities.

As an important component of bacterial lipopolysaccharide LPS, heptose is essential for the cell wall composition of gram-negative bacteria, bacterial infection and foodmate.

Septacidin is a secondary metabolite produced by gram-positive bacteria.

In 2020, the research team proved that the N6-glycosylated adenine structure of heptosecide was formed by the special Fe(II)-dependent glycosyltransferase SepE, and also proved that SepF is a novel glycosidase that can be hydrolyzed The CN glycosidic bond of the heptosidin precursor compound generates intermediate SEP-328.

Recently, the research group was invited by the authoritative review journal "Natural Products Reports" to write a review "Heptose-co"Ntaining bacterial natural products: structures, bioactivities, and biosyntheses" was published online.

Changes in glycosyl units can significantly affect the pharmacological properties of natural products.

Regarding the analysis of the formation mechanism of N6-glycosylated adenine in heptosecide, Dr.

(This article is reprinted by "Food Science Network", and the article is from the WeChat account of the Institute of Microbiology, Chinese Academy of Sciences.