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Individual studies have reported significant differences in venous thromboembolism (VTE) and bleeding rates in hospitalized patients with coronavirus disease (COVID-19) in 2019.
, what is the rate of VTE and bleeding in COVID-19 inpatients? In a recent study published in the authoritative respiratory journal Chest, researchers retrieved 15 standard and COVID-19-specific data sources between January 1, 2020 and July 31, 2020, without language restrictions.
researchers used a random effect meta-analysis to summarize morbidity estimates, used I2 statistics to assess the heterogeneity of the study, and used Begg and Egger tests to assess publishing bias.
VTE has a merger rate of 17.0% (95% confidence interval (CI) of 13.4%-20.9%), DVT has a merger rate of 12.1% (95% CI of 8.4%-16.4%) and PE is 7.4%. 1% (95% CI is 5.3%-9.1%), bleeding is 7.8% (95% CI is 2.6%-15.3%) and severe bleeding is 3.9% (95% CI is 1.2%-7.9%).
in the subgroup meta-analysis, the rate of VTE assessed through screening was higher in ICU patients (33.1% vs 9.8%).
the combined estimate of bleeding was reported to be highest (21.4%) in patients receiving moderate or full dose anticoagulant therapy, while the only prospective study to assess bleeding events was the lowest (2.7%).
result, the overall estimated combined rate of VTE was 17.0% among COVID-19 inpatients.
blood events were observed in 7.8 percent of patients, and other studies were needed to clarify the importance of various thrombosis events and to identify strategies to improve patient prognosis.