Chinese Academy of Sciences, Tsinghua University Nature publication found that Golgi-derived SEC14L2 vesicles regulate endocytosis division

Endosome, as a key member of intracellular vesicle transport, can precisely regulate the sorting of transported substances through morphological changes such as division and fusion, thereby affecting its intracellular transport pathway, including entering the lysosome for degradation, or transporting to Cell membranes or trans-Golgi bodies are recycled

June 28, 2021, Tsinghua University School of Life Jia Shunji associate researcher (Professor Meng Anming team) Joint Institute of Biophysics Laboratory researcher Li Dong in " Nature the Cell Biology on" a speech entitled "Golgi secretory vesicles through the promotion of phosphatidylinositol Inositol conversion mediates endosome fission (A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission)" research paper

In this study, the researchers used high-resolution imaging combined with electron microscopy to identify a vesicle derived from the Golgi apparatus and highly expressing SEC14L2, named SEC14L2 vesicle

Associate researcher Jia Shunji from the School of Life Sciences of Tsinghua University and researcher Li Dong from the Institute of Biophysics of the Chinese Academy of Sciences are the corresponding authors of the paper

The research was funded by the National Natural Science Foundation of China Major Research Program, the Ministry of Science and Technology Key Research and Development Program, and the Boxin Program

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Original link: https:// 

(Contribution: Li Dong's research group)