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"Chinese Products" for the Treatment of Spinal Cord Injury Seen Initial Results

 Last Update: 2021-09-11
 Source: Internet
 Author: User

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"In fact, there is no road on the ground.

Six years ago, the "crab" caught by Dai Jianwu, a researcher at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, and his collaborator "Wanglu" were getting mature

Chinese Academy of Sciences

Build a "bridge" for regeneration and restoration

The 24-year-old in the Mood for Love was dreaming, but a car accident caused Lin Li (a pseudonym) to have a cervical spinal cord injury.

There are many patients with traumatic spinal cord injury like Lin Li

As the main carrier of information communication between the brain and the peripheral nervous system, the spinal cord is often severely disabled after injury, and has always been considered an incurable disease

"As a scientist, the hope of patients and the hope of society are our goals

Facing this world problem in the medical field, Dai Jianwu and his team stepped up.

In order to break through the barrier of achievement transformation, they treated the laboratory as a "battlefield".

On January 16, 2015, this was an unforgettable day for Dai Jianwu

Say "no" to incurable diseases

"Safe!" "Preliminarily effective!" Recently, a paper published by the joint research team in the English version of "Science in China: Life Sciences" brought good news

In the new study, the Dai Jianwu team, together with the team of Professor Zhang Sai from the Armed Police Medical Characteristics Research Center, and the team of Professor Hou Shuxun from the Fourth Medical Center of the PLA General Hospital, conducted a study on 15 patients with acute complete spinal cord injury and 51 patients with old complete spinal cord injury.

"As far as I know, this is the first international report on the results of a large-scale long-term follow-up clinical study of stent material transplantation to repair complete spinal cord injury

For patients with spinal cord injury, usually in the Spinal Cord Injury Severity Assessment Standard ( ASIA), Grade A is considered to be a complete spinal cord injury (complete loss of motor, sensory, and sphincter function below the injury level)

In ASIA), Grade A is considered to be a complete spinal cord injury (complete loss of motor, sensory, and sphincter function below the injury level)

It is worth noting that the author stated that, unlike the time for patients to recover spontaneously after the shock phase of acute spinal cord injury, the sensory and motor function recovery of these patients appeared after two months, while the functional improvement of patients with spontaneous recovery mainly occurred in About 1 month after injury

Compared with acute spinal cord injury, it is more difficult to recover the function of old spinal cord injury clinically
.
Because of the scar tissue in the injured part, nerve regeneration and nerve function recovery are seriously hindered
.
In this regard, the research team used intraoperative neuroelectrophysiological methods to distinguish and appropriately remove scar tissue from normal nerve tissue.
The patient's neurological function was not significantly affected.
It was the first time that it was confirmed that scar removal in old patients is safe and feasible
.

At present, the research team has completed 51 patients with old complete spinal cord injury who have been followed up for more than 2 years, and none of them have found serious adverse reactions related to stent material transplantation and surgery
.
The sensory level of 16 of the 51 patients improved (accounting for 31 of the enrolled cases); 30 patients experienced improvement in autonomic nerve function such as increased reflex defecation sensation or increased sweating of the skin under the injury site (accounting for 59% of the enrolled cases); 43.
75% of patients with cervical spinal cord injury showed increased mobility of the fingers or shoulders, and some patients showed the expansion of motor evoked potential spinal cord segments
.

Many experts are very pleased with the results of this research
.
They pointed out that the regeneration and repair of spinal cord injury is a world-class problem.
Every bit of progress is precious and hard-won.
This research can provide valuable experience for subsequent clinical transfer research
.

A new round of medical revolution has come

Now, some patients with spinal cord injury of hope has been lit
.

Three months after implanting the collagen nerve regeneration scaffold, Lin Li's legs gradually recovered their motor function
.
After a year of rehabilitation, he can already walk with the assistance of two people
.
Similarly, Fang Hua (a pseudonym), 22 years old, suffered thoracic spinal cord injury due to a fall injury, completely paralyzed his lower limbs, and lost sensation in his urine and bowels
.
After stent surgery, his sensory evoked potentials and motor evoked potentials have begun to recover, and he can even walk independently after 9 months
.

"At present, classic medical treatments with drugs and surgical treatment as the basic pillars are far from meeting the huge needs of clinical medicine
.
Regenerative medicine research will help mankind realize the dream of repairing wounds and pathological tissues, curing end-stage diseases, and triggering continuous drugs and a new round of medical revolution after the surgery
.
" CAS vice president of Academician Zhou Qi pointed out
.

Chinese Academy of Sciences

At the same time, research on stem cells and regenerative medicine has become an important indicator for measuring the development level of a country’s life sciences and medicine, and developed countries around the world have invested heavily in the deployment of related research
.
"It can be said that whoever does it fast and who does it well will occupy the commanding heights
.
" Dai Jianwu said, in his view, the current regenerative medicine research on the central nervous system and reproductive system in China is at the forefront of the world
.

In the application field, the competition for the transformation of innovations in regenerative medicine is also becoming increasingly fierce
.
“At present, the nerve regeneration collagen scaffold is undergoing product transformation through Beijing Zhongke Zaikang Biotechnology Company
.
We hope that the nerve regeneration collagen scaffold product will benefit patients with spinal cord injury as soon as possible
.
” Dai Jianwu said
.
(Source: Feng Lifei, China Science News)

Related paper information: https://doi.
org/10.
1007/s11427-021-1985-5

https://doi.
org/10.
1007/s11427-021-1985-5 https://doi.
org/10.
1007/s11427-021-1985-5

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