Chinese researchers have discovered a new type of cholesterol-lowering compound

Professor Song Baoliang of Wuhan University's School of Life Sciences team found a powerful compound that promotes the degradation of cholesterol synthesis speed limit enzymes, which lowers cholesterol levels. The latest research was published online in nature Communications, an authoritative international journal.
high levels of cholesterol in the blood can lead to atherosclerosis, which in turn can lead to cardiovascular disease and
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. Statins are competitive inhibitors of speed-limiting enzymes in cholesterol synthesis, and are the main clinical cholesterol-lowering drugs, which are widely used in the prevention and treatment of cardiovascular diseases. However, statins can increase side effects after treatment.
after a series of compound design, optimization and activity analysis, the researchers found that the compound, in the mouse model of hypercholesterolemia and atherosclerosis, can reduce cholesterol levels and reduce the formation of atherosclerotic plaques. When applied in a combined form with statins, this compound further lowers cholesterol levels and reduces the formation of atherosclerotic plaques.
results show that inducing cholesterol-induced speed-limiting enzyme-degrading compounds is a new strategy for lowering cholesterol, especially with statins, which have a wide range of applications in the treatment of cardiovascular disease. Currently, the screening systems and compounds associated with this study have been patented.