Chinese scholar Nature published important results to decipher the mechanism of chitinous biosynthesis

On September 21, Nature published the latest achievements of the team of Yang Qing of the Institute of Plant Protection of the Chinese Academy of Agricultural Sciences and the Shenzhen Institute of Agricultural Genome in the form of a long research article
.

Chitin, commonly known as chitin, is the richest aminoglycan
on earth.

The study selected the chitin synthetase PsChs1 of Phytophthora sojae as the research object
.

Kang Le, academician of the Chinese Academy of Sciences, foreign academician of the American Academy of Sciences, and president of Hebei University, pointed out that the biosynthesis of chitinin is an extremely ancient and conservative way, and egg fungi may be the lowest organism
that can synthesize chitin.

Song Bao'an, academician of the Chinese Academy of Engineering and president of Guizhou University, pointed out that the development and utilization of green pesticide molecular targets has become a major demand of the country, and a new target can not only give birth to dozens or even hundreds of pesticide varieties, but also greatly alleviate the drug resistance of
existing pesticide varieties 。 The study analyzes the three-dimensional structure of a recognized green pesticide molecular target - chitinic synthase, elucidates the mechanism of chitinous biosynthesis and the mechanism of action of inhibitors, which is a milestone for Chinese scientists in the field of pesticide molecular target research, which is conducive to creating heavyweight green pesticide varieties, enhancing the core competitiveness of China's pesticide industry and the ability to prevent and control agricultural harmful organisms, and ensuring China's food security
.

Qian Xuhong, academician of the Chinese Academy of Engineering and president of East China Normal University, pointed out that the research broke through a bottleneck in the field of chitinous pesticides in the field of nearly 50 years, and through the analysis of the binding mode of chitinous synthetase with substrates, products and inhibitors at the atomic scale, it provided a stage for the realization of the dream of eco-friendly pesticides that mankind has not realized for decades: the structure of chitinic synthetase is based on the precise design of green pesticides
.

The research has been funded
by the National Natural Science Foundation of China, the International (Regional) Cooperation and Exchange Project, the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences, the Shenzhen Science and Technology Plan Project, and the Shenzhen Dapeng New Area Science and Technology Innovation and Industrial Development Special Fund.

Three-dimensional structure of PsChs1 and the mechanism of chitinous synthesis

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