Chinese scholars found Yap inhibitors of proto oncoprotein

Zhou Zhaocai, Zhang Leiyan and Ji Hongbin of Shanghai Institute of Biochemistry and cell research, Chinese Academy of Sciences and national protein science center, recently found an inhibitor of Yap, a proto oncoprotein, which provides a new way for cancer treatment represented by gastric cancer Relevant research papers have been published online in the international academic journal cancer cells Hippo signaling pathway is an important anti-cancer pathway found in recent years Proto oncoprotein Yap is the main downstream effector molecule Its abnormal expression is closely related to gastric cancer, lung cancer and other cancers, and it is a potential molecular target for tumor treatment Therefore, Yap targeted inhibitors may be able to more directly correct the maladjusted Hippo signaling pathway and kill tumors Gastric cancer is a malignant tumor with the highest mortality rate At present, there is no effective treatment for gastric cancer in the world Researchers from three research groups found that vgll4, a natural antagonist protein, was down-regulated in gastric cancer tissues, and negatively correlated with the development and deterioration of the tumor It was a potential tumor suppressor protein It turns out that vgll4 can control Yap activity "switch" in advance, thus inhibiting tumor cell growth Therefore, on the basis of three-dimensional structure analysis of protein crystal, researchers designed and developed a peptide inhibitor aiming at Yap, which can simulate the function of natural antagonist protein vgll4 and carry out therapeutic intervention Subsequently, the researchers used a variety of technical means, using a number of mouse animal models, to confirm that this polypeptide inhibitor can effectively inhibit tumor growth Further pharmacological and toxicological evaluation also confirmed the specific sensitivity of cancer cells with imbalanced characteristics to the inhibitor It is reported that this study provides a new option for the treatment of gastric cancer, and may also provide personalized treatment strategies for other similar features of cancer At present, relevant research results have been patented.