Funded by the National Natural Science Foundation of China (Grant Nos.
Cardiovascular and cerebrovascular events are the main cause of sudden death, and acute thrombosis is the key link
The research team first discovered in clinical studies that there is a special circadian clock nuclear receptor Rev-erbα in healthy human platelets
Using small molecule-protein docking technology, the team found that a specific inhibitor of Rev-erbα could inhibit this activation pathway, thereby significantly inhibiting human platelet activation and thrombosis in vitro
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