Chinese scholars have made progress in the research of cochlear implant electroacoustic stimulation to promote the growth of auditory spiral neurons

Figure Cochlear implant electroacoustic stimulation promotes spiral neuron growth and signal transmission

With the support of the National Natural Science Foundation of China (grant numbers: 82030029, 81970882, 81970883), Professor Chai Renjie of Zhongda Hospital Affiliated to Southeast University, together with Professor Gao Xia of Gulou Hospital Affiliated to Nanjing University, Professor Sun Shan of Otolaryngology Hospital Affiliated to Fudan University and Professor Tang Mingming of Soochow Universityhave made progress in the research of electroacoustic stimulation of cochlear implants to promote the growth of spiral neurons T_xMXene-matrigel in combination with electroacoustic stimulation promotes helical ganglion neuron growth(3D Ti3C2Tx MXene-matrigel with electroacoustic stimulation to promote the growth of spiral ganglion neurons", published
in the journal ACS nano.
Links to papers: https://pubs.
acs.
org/doi/10.
1021/acsnano.
2c06306
.

The research team used Ti3_C2T x MXene to adjust the physicochemical characteristics of Matrix hydrogel, and constructed an electroacoustic stimulation three-dimensional culture system
combining cochlear implant and conductive Ti₃C₂T_xMXene-Matrigel composite hydrogel.
The helical ganglion neuron (SGN) is cultured in aTi3C2T_xMXene-Matrigel complex hydrogel and applied electroacoustic stimulation
of cochlear implant transduction.
The results showed that the system showed excellent biocompatibility, and low-frequency electroacoustic stimulation could promote the development of SGN growth cones and neurite growth
.
Further experiments have found that low-frequency electroacoustic stimulation also increases the synaptic density of SGN in the system and promotes calcium-mediated signaling between cells (Fig.
).

This study has potential clinical application value
for Ti_{3C2T x}MXene-Matrigel composite hydrogel to optimize hearing after cochlear implantation.