Chinese scholars have revealed the characteristics of adaptive immune response to neo-corona pneumonia

Xinhua, August 18 (Reporter Shi Weifu) Harbin University of Technology announced on the 18th, the university's Professor Huang Zhiwei team on the latest research results of the new crown pneumonia, with "the new crown pneumonia severe and mild patients with the adaptive immune response to the new coronavirus infection" published online in the "Signal Transduction and Targeting Therapy" magazine. This study is important for understanding the pathogenesis and rehabilitation mechanisms of patients with neo-coronary pneumonia, as well as for designing vaccines and therapeutic drugs to combat SARS-CoV-2 infections.
To study the adaptive immune response mechanism for SARS-CoV-2 infection in PATIENT-CoV-2 patients and the establishment of immune memory in recovering patients, the team first studied the response mechanism of adaptive immune cells in the outer blood of PATIENTs with different severity of the disease.
The study first found that the proportion of killer T-cell subtastes expressing cytotoxic molecules in COVID-19 patients increased compared to healthy people, indicating that the proliferation of these killer T-cells was associated with COVID-19, and a significant decrease in mucosal-related constant T lymphocytes in COVID-19 patients showed that the adaptive immune system in COVID-19 patients did not fully recover at the early stage of recovery.
In addition, the study also found that different COVID-19 patients have a large heterogeneity of antiviral response, but also suggested that different individuals have different antiviral response mechanisms, to follow up on the larger cohort study put forward more possibilities.
this study is important for understanding the pathogenesis and rehabilitation mechanisms of severe and mild patients with neo-corona pneumonia, as well as for the design of vaccines and therapeutic drugs to combat SARS-CoV-2 infections.