Chinese scholars reveal the regulatory network and markers of the heartbeat "center"

The human heart beats 60 to 100 times per minute, delivering blood to organs throughout the body and maintaining normal functioning of life. The heart beat control "center" or "supreme command" for sinus knots. Sinus knots were discovered more than a century ago, but so far academic understanding of them has been rather poor. Sinus knots are located in the adricle, sinus knots are not only small in size, their substantive cells are also very few, and cell separation and functional analysis is more difficult, which hinders the international research process on sinus knots.
Recently, with the help of pacing cell separation technology, single-cell transcription group sequencing and analysis technology, cytoimaging technology, gene modification technology, cell-induced differentiation technology and series of electrophysiological techniques, to analyze the core gene regulation network of sinus cells from the single-cell resolution level, and discovered the biomarkers of the potentially important prospects of sinus cells. The findings were published online online in Nature -Newsletter.
a number of questions that plague the field of sinus cell biology and medical research, such as: What kind of molecular cell system does sinus cell cells have? Does the sinus room pacing cells really have an advantage in excited "dominant clusters"? What is the core gene regulation network that controls the function of sinus cells? What are the biomarkers specific to sinus cells?
a new study by researchers at Tongji University in Theory of Science and Technology has revealed cluster types and molecular systems of sinus-house pacing cells in three species, from rats to rabbits to monkeys. Using information technology and functional verification, the researchers initially demonstrated that the sinus cells of different species contained a "dominant cluster" that controls heart beats, and they found that the cells of these clusters were scattered in different areas of the sinus cell nodes, a distribution that may be beneficial to the steady state of the heartbeat. The researchers identified a core gene regulatory network that controls heart beats, where individual molecules have been shown to significantly regulate the frequency of heartbeats. At the same time, the researchers also found biomarkers of sinus cells, suggesting that Vsnl1 may be a biomarker that can be used to identify pacing cells and explore arrhythmic disorders.
experts say the findings provide the basis for sinus knot research and contribute to in-depth exploration of sinus cell biology, pathology and therapeutics.
It is learnt that the authors of the paper are Chen Yihan of Tongji University School of Medicine and Tongji University Oriental Hospital, Professor Xue Zhigang of Tongji University School of Medicine, and the first author is Liang Dandan Researcher of Tongji University Affiliated Oriental Hospital. (Source: Huang Xin, China Science Journal)
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