China News Service, September 10 (Sun Guogen, Chen Jing) The reporter learned on the 10th that the scientific research team of Professor Xu Jiejie, School of Basic Medicine, Fudan University, has discovered the immune escape of gastric cancer in a large sample, multi-center study involving many gastric cancer patients.
It is reported that related research papers have recently been published online in the latest issue of the international academic journal "European Journal of Cancer" (European Journal of Cancer)
According to Xu Jiejie, postoperative survival assessment, chemotherapy response prediction, and treatment options for patients insensitive to chemotherapy are the three major challenges in the clinical diagnosis and treatment of gastric cancer
The expert said that the individual differences of gastric cancer patients and the high heterogeneity of gastric cancer itself determine that only individualized treatment can be used to obtain the best therapeutic effect
The research team found that the CD73 protein in the immune microenvironment of gastric cancer can "instigate" the "warriors" who kill tumors, thereby reducing the secretion of key factors that exert anti-tumor immune functions, and making the immune response that can effectively kill tumors appear "immune brake" , Leading to a poor prognosis for patients
It is reported that the results of this research provide new ideas for the optimization of prognostic prediction models for gastric cancer patients and the development of individualized treatment strategies
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