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    Home > Medical News > Medical Science News > Chinese scientists have successfully developed a new coronary antibody cocktail therapy

    Chinese scientists have successfully developed a new coronary antibody cocktail therapy

    • Last Update: 2021-02-10
    • Source: Internet
    • Author: User
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    Huang Zhong Research Group, Shanghai Pasteur Institute, Chinese Academy of Sciences,
    Molecular Cell Science Innovation Center, Xie Yuhua Group of Fudan University School of Medicine and Deng Qiang Research Group have worked together to develop a two-antibody cocktail therapy that can be used to treat new coronavirus infections, based on freezing The analysis of high-resolution structure and bio-chemical analysis of electroscope illustrates the mesification mechanism of 2H2/3C1 antibody, and for the first time captures the dynamic process of the new coronavirus pyrethroid triple cluster triggered by antibody through gradual re-configuration and co-binding antibody, which has important theoretical significance and clinical transformation value. The findings were published online online in Nature -Newsletter.
    new crown pneumonia caused by the new coronavirus in the global pandemic, the cumulative number of infections has exceeded 104 million, the death toll of more than 2.27 million, a serious threat to global public health.
    neutral antibodies against the new coronavirus have the advantages of clear targeting and significant drug ability, ebola virus treatment drugs based on monoclonal antibody combinations have been approved for market. Therefore, the development of new coronavirus and antibodies as a potential treatment against new coronary pneumonia is high hopes.
    early work by the team found that the binding domain (RBD) recombinant protein immune mice on the prickly protein (S protein) of the new coronavirus were able to induce the production of highly priced, meso-antibodies.
    the study, the researchers isolated five neutral monoantitors from RBD-immune mice and divided five monoantitors into two groups through antibody competition experiments and mutant-based esogen identification experiments. The representative monoantibodies 2H2 and 3C1 of the two antibody groups identify different cousins on RBD and can be combined into non-competitive antibody pairs.
    half of the inhibited concentrations of humanized modified 2H2/3C1 antibodies combined in-body and neo-coronavirus live viruses were 12 gram per milliliter. What's more, the 2H2/3C1 antibody combination has strong antiviral activity in the new coronavirus mouse infection model, even if the mice infected with the new coronavirus 24 hours after injection of 2H2/3C1 antibody cocktail, can still significantly reduce the viral load, play a therapeutic role.
    time, the researchers analyzed a series of 2H2 or 3C1 single-resistant antigen binding fragments combined with the new coronavirus S triggle to form a complex of frozen electron mirror structure, resolution of 3.8 E.
    Huang Zhong researchers said that the above structural studies clear 2H2 and 3C1 monoantigen binding table, the first time to capture the antibody triggered by the new coronavirus S triple polymer composition change space, and through the gradual re-configuration and then co-binding antibody dynamic process, revealed the 2H2/3C1 antibody cocktail synergy and the potential molecular mechanism of the new coronavirus. (Source: Huang Xin, China Science Journal)
    related paper information:
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