Chinese scientists reveal 'developmental cell map' of human digestive tract

types of cells in the human digestive tract? What do they look like when they're "long"? After many years of joint research, Chinese scientists recently in the international community for the first time a comprehensive and systematic clarification of the esoeso while the stomach, small intestine and large intestine four organs in the human embryo development process of gene expression map and its signal regulation mechanism, for the research field of digestive tract biology to provide a comprehensive and informative developmental cell map data.
research results obtained by the Beijing Future Gene Diagnostics High-Sophisticated Innovation Center (ICG), Beijing University Biodynical Optical Imaging Center and Peking University Third Hospital were published recently in
, an internationally renowned academic journal.
The digestive tract is the most important component of the human digestive system, mainly composed of the esoesogram, stomach, small intestine and large intestine, revealing the gene expression control network and "cell type map" of these four organs in the development of human embryos, which is one of the major problems in the field of developmental biology.
" study is the first time in the world in single-cell resolution and full transcription group conditions, a comprehensive and systematic disclosure of the four organs between different cell types of precise development pathways and gene expression characteristics. "For many years, Professor Tang Fufu, deputy director of the Beijing Center for High-Sophisticated Innovation in Future Genetic Diagnostics, has been working on the development of human early embryos and reproductive systems in single-cell functional genomics.
researchers first isolated and obtained a total of 5,277 single cells in the esoviruse, stomach, small intestine, large intestine and adult large intestine in human embryos between 6 and 25 weeks, and sequenced them with high-precision single-cell transcription groups, obtaining up to 5T gene expression spectrum data.
based on the in-depth excavation of the large amount of data, the research team analyzed the development process of these four organs in a comprehensive and systematic way at the level of gene expression regulation, and made many important discoveries. For example, 40 different important cell types were identified for these four organs, including 30 cell types during human embryonic development, and for the first time, the development of the large intestine from fetus to adult was systematically studied, with the identification of 10 major cell types in the adult large intestine.
" study provides an accurate map of normal cells in the digestive tract for researchers to compare, providing an important criterion for identifying the gene expression characteristics of digestive tract cells produced by introspection of erypotent stem cells. Tang said.
and findings of these scientists also provide important reference for the study of four types of digestive organ-related cancers, especially the cancerous pathogenesis of colorectal cancer.
to treat bowel cancer, you have to figure out the cancer cells, which need to be compared with normal cells. Tang said. (Source: Xinhua News Agency, Wei Mengjia)