Chunfu Zheng publishes vaccine design targeting pathogenic fungal FTR1 in Frontiers in Immunology

Recently, Professor Chunfu Zheng/Professor Hosen from Bangladesh published Immunoinformatic Design of a Multivalent Peptide Vaccine Against Mucormycosis: Targeting FTR1 Protein of all Causative Fungi in Frontiers in Immunology.
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Black mold is a potentially fatal disease that is susceptible to infection in immunocompromised people, such as diabetic ketoacidosis, neutropenia, and organ transplant patients
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The sudden spread of black mold in COVID-19 patients has attracted worldwide attention
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Elevated serum ferritin concentrations in diabetes, cancer, steroid medications, chronic ventilation, and comorbidities in patients with COVID-19 can promote fungal growth that can lead to black mold
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A recent study found that the ferrous permease encoded by the FTR1 gene is necessary for fungi to acquire host iron
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Unfortunately, there is currently no suitable antifungal vaccine
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Therefore, based on immunoinformatics against four different pathogenic fungi, a convenient and novel epitope vaccine was designed targeting the FTR1 protein
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The vaccine is constructed using 8 CTL, 2 HTL and 1 LBL epitopes that are highly antigenic, non-allergic, avirulent and fully conserved among these fungi
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Due to the high pI (9.
97) value of this vaccine, it has very good stability
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Conduct molecular docking, molecular dynamics and immune simulation studies on the vaccine to confirm its safety, efficacy and stability
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In addition to being effective, the vaccine structure is also safe
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Finally, we use in silico cloning to simulate vaccine large-scale production
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The vaccine designed in this study will be a potential treatment not only to control black mold in COVID-19 patients, but also to be effective against black mold in general
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However, further in vitro and in vivo testing is needed to confirm the safety and efficacy of the vaccine in controlling fungal infections
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If successful, the vaccine could provide a low-cost and effective way to prevent the global spread of black mold
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 Schematic diagram of vaccine design experiment Vaccine structure diagram Fine 3D structure of black mold vaccine Interaction between black mold vaccine and TLR 3D conformation diagram of black mold vaccine B cell epitope Article link: https:// /10.
3389/fimmu.
2022.
863234/abstract heavyweight: Professor Zheng Chunfu selected as 2022 Top 100K Global Top Scientist Corresponding author: Professor Zheng Chunfu, selected as 2022 Top 100K Global Top Scientist, winner of "Hundred Talents Program" of Chinese Academy of Sciences (2007), University of Canada of Calgary, adjunct professor, served as the editor and editorial board member of several SCI journals: 1.
mBio editor (zero breakthrough of local editors in mainland China), 2.
Journal of Virology editorial board, (2015-2024), (no prior to 2015) Chinese local editor) 3.
Associate Editor of Frontiers in Microbiology; 4.
Associate Editor of Frontiers in Immunology; 5.
Associate Editor of Virology Journal; 6.
Associate Editor of Journal of Medical Virology; 7.
Editorial Board Member of Military Medical Research; 8.
Gene, Protein and Disease Deputy Editor; in addition, Zheng Chunfu participated in the review of dozens of SCI journals, such as Advanced Material, Cell host & Microbe, Seminar in Immunology, Microbiome, Cell Report, cellular and Molecular Immunology, PLoS Pathogen, Molecular Therapy, Acta Pharmaceutica Sinica B, Theranostics, Reviews in Medical Virology, et al
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Since he started as editor in 2011, he has edited and reviewed more than 573 (303+270) articles
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 Chunfu Zheng won the 2019 Global Publons Peer Review Award (TOP1% in the field of microbiology), and was listed on the Journal of Virology's annual peer review rankings for three consecutive years from 2019 to 2021 (TOP25, with 15-20 papers reviewed annually)
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Professor Chunfu Zheng has made breakthroughs in the study of the molecular mechanism of the interaction between herpes simplex virus type I (HSV-1) infection and the host, and the study of HSV-1 escaping the host's antiviral innate immunity.
In Trends in Microbiology (IF 17.
257), Microbiology and Molecular Biology Reviews (cover article, IF 12.
568), FEMS Microbiology Reviews (IF 16.
408), Blood (IF 23.
629), Cell Host & Microbe (IF 29.
160), Journal of Medical Virology (immediate IF 17.
909), Cytokine & Growth Factor Reviews (immediate IF 16.
458), Reviews in Medical Virology (immediate IF 9.
858), Proceedings of the National Academy of Sciences USA (IF 12.
173), mBio (IF 7.
867), Journal of Biomedical Science (immediate IF 11.
792), Cellular and Molecular Life Sciences (IF 9.
206), Journal of Virology (23 papers, 2 of which are highlights; IF 5.
103), Journal of Immunology (2 papers, IF 5.
422), Protein and Cell (IF 14.
870; 2 papers), and other mainstream journals published in SCI He has published more than 110 papers, with a total of more than 2,700 citations and an H-index of 28
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The website of Prof.
Chunfu Zheng's laboratory: https://bms.
fjmu.
edu.
cn/2017/1130/c2905a72170/page.
htm The topics of Prof.
Chunfu Zheng's recent manuscripts are as follows: 1.
Molecular mechanism of antiviral innate immune recognition and regulation and viral pathogenesis Immune Evasion https:// Virology and Antiviral Innate Immunity Assays https://www .
jove.
com/methods-collections/1731/current-experimental-methods-techniques-for-basic-virology-antiviral3.
Herpes virus vaccine development topic https:// characteristics-and-immune-recognition-of-human-herpes-virus-structure-proteins It is worth mentioning that Professor Zheng Chunfu’s article just published 3 months ago has been cited 48 times: