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CID: Efficacy and safety of gentamicin combined with azithromycin and gemifloxacin combined with azithromycin in the treatment of simple gonorrhea

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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Effective control and prevention of gonorrhea depend on timely and effective antibacterial treatment
.

However, since the introduction of antibacterial drugs in the 1930s, gonorrhea has gradually developed resistance to every type of therapeutic drug , including sulfonamides, penicillins, tetracyclines, and second-generation fluoroquinolones, such as ciprofloxacin

Effective control and prevention of gonorrhea depend on timely and effective antibacterial treatment

Purpose: Ceftriaxone is currently the recommended basic treatment for gonorrhea

Results: Among 202 participants who received gentamicin/azithromycin treatment, the microbial cure rate was 100% (one-sided exact 95% lower confidence interval, 98.
5%); 199 participants who received gemifloxacin/azithromycin treatment Among them, the microbial cure rate was 99.
5% (one-sided exact lower limit of 95% confidence interval, 97.
6%)
.

Gentamicin/azithromycin cured 10 pharyngeal infections and 1 rectal infection, and gemifloxacin/azithromycin cured 15 pharyngeal infections and 5 rectal infections

Table 1 Percentage of participants who analyzed and reported adverse events and severity

Table 2 Antimicrobial susceptibility of Neisseria gonorrhoeae collected from participants analyzed by Per protocol (n = 421)

Conclusion: Gentamicin/azithromycin and gemifloxacin/azithromycin are effective in the treatment of genitourinary gonorrhea
.

Adverse gastrointestinal events may limit its routine use

Gentamicin/azithromycin and gemifloxacin/azithromycin are effective in the treatment of genitourinary gonorrhea

Kirkcaldy RD, Weinstock HS, Moore PC,et al, The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea .

The efficacy and safety of gentamicin plus azithromycin and gemifloxacin plus azithromycin as treatment of uncomplicated gonorrhea in this message

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