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    Home > Active Ingredient News > Anesthesia Topics > [Classic high score literature reading] Under the action of spontaneous breathing, volatile anesthetics can maintain tidal volume and minute ventilation better than propofol

    [Classic high score literature reading] Under the action of spontaneous breathing, volatile anesthetics can maintain tidal volume and minute ventilation better than propofol

    • Last Update: 2022-01-10
    • Source: Internet
    • Author: User
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    Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration.
    Volatile anesthetics maintain tidal volume and minute ventilation better than propofol under spontaneous respiration.
    Concepts related to MAC ①MAC: The lowest alveolar concentration of inhalation anesthetics that can make 50% of patients have no response to standardized stimuli (such as skin incision), about 1MAC
    .

    ②MAC awake95: The alveolar gas anesthetic concentration when 95% of patients can open their eyes to simple instructions MACawake = 0.
    4 MAC ③ED50 (half effective dose): the dose that causes 50% of the positive response (qualitative response) or 50% of the maximum effect (quantity response) Or concentration
    .

    1.
    Background Although systemic anesthetics inhibit spontaneous breathing, the comprehensive effect of systemic anesthetics on respiratory function is still unclear
    .

    Objective To investigate the effect of general anesthetics on spontaneous respiration in different types and doses of non-intubated mice
    .

    2.
    Methods Adult C57BL/6J mice were injected intravenous anesthetics (propofol and etomidate), inhalation anesthetics (0.
    5, 1.
    0, 2.
    0 MAC/ED50 sevoflurane and isoflurane) to reduce the righting reflex
    .

    Whole body plethysmography (WBP) was used to measure respiratory parameters without tracheal intubation
    .

    At the same time, the change of the patient's respiratory sensitivity to CO2 under general anesthesia was measured
    .

    Continuously record the following respiratory parameters during anesthesia or CO2 exposure: respiratory rate (FR), tidal volume (TV), minute ventilation (MV), expiratory time (TE), inspiratory time (TI), inhalation-exhalation Time ratio (I/E) and peak inspiratory frequency
    .

    3.
    Results Sevoflurane or isoflurane at a subanaesthetic concentration of 0.
    5MAC increased respiratory rate (FR), tidal volume (TV), and minute ventilation (MV)
    .

    Under sevoflurane or isoflurane anesthesia, as the concentration of CO2 increases, respiratory rate (FR), tidal volume (TV), and minute ventilation (MV) decrease
    .

    Propofol and etomidate cause respiratory depression, which is manifested as a decrease in inhalation frequency (FR), tidal volume (TV), and minute ventilation (MV)
    .

    During ventilation with pure oxygen (100% O2), the respiratory rate (FR) of propofol and etomidate receiving 1.
    0ED50 were 69.
    63±33.
    44 breaths/min and 55.
    68±64.
    42 breaths/min, respectively
    .

    In 3% CO2 ventilation, the rates were 88.
    72±34.
    51 beats/min and 225.
    10±59.
    82 beats/min
    .

    In 5% CO2 ventilation, they were 144.
    17±63.
    25 beats/min and 197.
    70±41.
    93 beats/min
    .

    Compared with the propofol group, the etomidate group mice were more sensitive to CO2
    .

    Compared with the same dose of etomidate, sevoflurane and isoflurane, propofol caused a greater decrease in respiratory rate (FR), minute ventilation (MV), and inspiratory-expiratory time ratio (I/E) Big
    .

    4.
    Conclusion The regulation of spontaneous breathing by general anesthesia is different
    .

    Inhalational anesthetics increase respiratory rate (FR), tidal volume (TV), and minute ventilation (MV) at sub-anaesthetic concentrations, while suppressing these respiratory parameters at higher concentrations
    .

    Propofol inhibited respiratory parameters more than etomidate
    .

    5.
    Figure & Table F1.
    MAC comparison of sevoflurane and isoflurane F2.
    The effect of sevoflurane on respiratory function is dose-dependent F3.
    The effect of isoflurane on respiratory function is dose-dependent F4.
    Intravenous anesthetics on respiration in vivo Effect of reaction F5F6END
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