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Clin Cancer Res: According to the implantation of the transplanted tumor of the patient's source, predict the patient's tumor recurrence risk?

 Last Update: 2021-09-12
 Source: Internet
 Author: User

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Patient-derived xenograft tumors (PDX) are an important tool for studying the biology and drug response phenotypes of different solid tumors

This is a study of breast cancer patients treated with neoadjuvant chemotherapy (NAC; taxane ± trastuzumab) followed by anthracycline chemotherapy .

Breast cancer

Cumulative incidence of breast cancer recurrence events grouped by PDX implantation or not

After a median follow-up of 5.

In the pre-NAC PDX subgroup, according to whether PDX was successfully implanted or not, there was no significant difference in the cumulative recurrence rate of breast cancer.

Cumulative incidence of breast cancer events in patients with residual lesions after NAC treatment

In the PDX subgroup after NAC, patients with successful PDX implantation had a higher incidence of breast cancer events (5-year recurrence rate: 50.

In the PDX subgroup after NAC, patients with successful PDX implantation had a higher incidence of breast cancer events.

Original source:

Judy C.

Patient-Derived Xenograft Engraftment and Breast Cancer Outcomes in a Prospective Neoadjuvant Study (BEAUTY)

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