 Home > Active Ingredient News > Antitumor Therapy > Clin Cancer Res: base excision repair inhibitor TRC102 combined with pemetrexed-cisplatin-radiotherapy standard regimen for the treatment of advanced non-squamous non-small cell lung cancer

Clin Cancer Res: base excision repair inhibitor TRC102 combined with pemetrexed-cisplatin-radiotherapy standard regimen for the treatment of advanced non-squamous non-small cell lung cancer

 Last Update: 2021-12-04
 Source: Internet
 Author: User

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Lung cancer remains the leading cause of cancer-related deaths worldwide (about 1.

TRC102 is a small molecule base excision repair inhibitor.

This is a phase I clinical trial that evaluated the optimal dose, efficacy and safety of pemetrexed and TRC102 combined with cisplatin radiotherapy in the treatment of stage III non-squamous non-small cell lung cancer (NS-NSCLC)

Progression-free survival

From 2015 to 2019, a total of 15 patients were recruited

3 patients achieved complete remission (20%), 12 patients achieved partial remission (80%), 3 patients achieved complete remission (20%), and 12 patients achieved partial remission (80%) for 6 months The progression-free survival rate was 80%, and the 2-year overall productivity was 83%

Overall survival rate

In summary, the safety and tolerability of pemetrexed combined with TRC102, cisplatin and radiotherapy for non-squamous non-small cell lung cancer are good

The safety and tolerability of pemetrexed combined with TRC102 and cisplatin and radiotherapy for non-squamous cell carcinoma and non-small cell lung cancer are well tolerated Both safety and tolerability are good

Original source:

Biswas Tithi,Dowlati Afshin,Kunos Charles A et al.

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