Clin Immunol: Pre-transplant immunology assessment can identify kidney transplant recipients at risk of CMV infection after transplantation.

Assessing CMV-specific T-cell immunity may be a useful tool for predicting CMV infection after solid organ transplantation.
forward-looking study, which looked at the reactions of CD4 and CD8 T cells to CMV pp65 and IE-1 antigens, was published online in J Hosp Infect.
study included 28 CMV serum-positive kidney transplant recipients who received expendable antibodies (Thymoglobulin®) as induction therapy and generally prevented CMV infection.
the reactions produced by THEFN-24 months after transplantation using in-cell flow cytometers and 1, 6, 12 and 24 months γ transplantation.
results showed that only the response of CD4 T cells to pp65 before transplantation was significantly reduced in patients with CMV replication after transplantation (p s.004).
ROC curve analysis shows that the pre-transplant pp65-specific CD4-T cell frequency is less than 0.10%, cmV infection can be predicted, its sensitivity is 75%, the specificity is 83.33% (A UC:0.847;95%CI:0.693-1.001; p -.0054) seems to be a prerequisite for the host immune system to effectively control the replication of the CMV virus.
In summary, a functional evaluation of CMV-specific CD4 T cell immunity before serum-positive patients can identify kidney transplant recipients treated with thymus globulin® who are at risk of CMV infection after transplantation.
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