Clin pharmaceutical her: Alert! Drug interactions can cause hypotension!

April 15, 2019 / BIOON / - the most commonly used muscle relaxant, tizanidine, can reduce blood pressure Tettonidine is metabolized by CYP1A2, and the existing combination of tettonidine and CYP1A2 inhibitors (such as ciprofloxacin, the commonly used strong CYP1A2 inhibitor) can significantly improve the plasma concentration of tettonidine Despite the warnings on the package, tizanidine and CYP1A2 inhibitors are usually co prescribed Source: http://cn.bing.com Dr Cecilia Chung and colleagues used electronic health record data to study the risk of hypotension in patients taking both tizanidine and ciprofloxacin They found that patients who used tizanidine had a higher risk of severe hypotension than those who used ciprofloxacin, while patients who used three or more antihypertensive drugs or had other complications had a higher risk of severe hypotension The findings, published recently in Clinical Pharmacology & Therapeutics, confirm the interaction between tettonidine and strong CYP1A2 inhibitors in routine clinical practice Clinicians should avoid prescribing both drugs at the same time, especially in patients with a higher risk of severe hypotension Reference: sandip chaugai et al Co prescription of strong CYP1A2 inhibitors and the risk of tizanidine associated hypertension: a retrospective cohort study, clinical pharmacology & Therapeutics (2018) Doi: 10.1002/cpt.1233