Colon cancer risk is related to antibiotic use

"The results of the study emphasize the fact that there are many reasons for restricting the use of antibiotics
.

Although in many cases antibiotic treatment is necessary and can save lives, if there is a less serious disease, it can be cured anyway and you should be cautious.

Researchers found that women and men who took antibiotics for more than 6 months had a 17% higher risk of ascending colon cancer than those who did not take any antibiotics
.

However, the cancer risk of the descending colon has not increased

After taking antibiotics for 5 to 10 years, the increased risk of colon cancer is already obvious
.

Although the risk increase is greatest among the people taking the most antibiotics, it is also possible to observe that after taking a course of antibiotics, the increase in cancer risk is small, but statistically significant

"There is evidence that the use of antibiotics may increase the risk of colorectal cancer by changing the intestinal microbiota
.

The researchers wrote that the purpose of our study was to investigate the relationship between antibiotic use and the risk of secondary colorectal cancer

"This is a nationwide, population-based study, using a matched case-control design (1 primary CRC case and 5 matched cancer-free controls)
.

From 2005 to 2016, the Swedish national registry data The extracted complete population data is used to calculate odds ratio and 95% confidence interval

"We included 40,545 CRC cases and 202,720 controls
.

Using the complete data set, we found a positive correlation between more frequent use of antibiotics and colorectal cancer.

"Quinolones, sulfa drugs, and/or trimethoprim are positively correlated with proximal colon cancer, while a more general inverse correlation has been observed in rectal cancer, in all antibiotic classes
.

We did not find methyl hippurate The link between amphetamine (a urinary tract preservative that does not affect the gut microbiota) and the risk of colorectal cancer

“This study based on the registered population covered the entire population of Sweden and found a strong association between antibiotic use and a high risk of proximal colon cancer, as well as an inverse association with rectal cancer in women
.

This study reinforces previous investigations.

In order to understand how antibiotics increase the risk, the researchers also studied a non-antibiotic bactericidal drug used to treat urinary tract infections, which does not affect the microbiota
.
There is no difference in the frequency of colon cancer among people taking the drug, which suggests that the effect of antibiotics on the microbiota increases the risk of cancer
.
Although this study only covers oral antibiotics, even intravenous antibiotics may affect the intestinal flora of the intestinal system
.

"There is absolutely no reason to panic just because you took antibiotics," Harlid said
.
"The increase in risk is modest, and the impact on the absolute risk of individuals is quite small
.
Sweden is also introducing routine screening for colorectal cancer
.
Just like any other screening program, participation in screening is very important, so that any cancer is It can be detected and even prevented early, because cancer precursors can sometimes be removed
.
"