Comparative analysis and diagnosis model establishment of membranous nephropathy and other types of nephropathy

FMD | Comparative analysis and diagnosis model establishment of membranous nephropathy and other types of nephropathy

FMD | Comparative analysis and diagnosis model establishment of membranous nephropathy and other types of nephropathy FMD | Comparative analysis and diagnosis model establishment of membranous nephropathy and other types of nephropathy

Paper Title: Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model (Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model)

Journal: Frontiers of Medicine

Frontiers of Medicine Frontiers of Medicine Frontiers of Medicine

Authors: Hanyu Zhu (), Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen (), Dong Zhang

Posting time: 09 Aug 2018

DOI: 10.
1007/s11684-018-0620-5

10.
1007/s11684-018-0620-5 10.
1007/s11684-018-0620-5

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Zhu Hanyu and Chen Xiangmei, Department of Nephrology, General Hospital of the Chinese People’s Liberation Army, published a research paper " Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic " in Frontiers of Medicine.
model )
.

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Membranous nephropathy is one of the common chronic kidney diseases.
The gold standard for diagnosis is renal biopsy puncture, but it has not been widely used because of its invasiveness and complicated operation
.

The non-invasive diagnostic model established in this study through Logistic regression analysis can effectively diagnose membranous nephropathy with high sensitivity and specificity, and has a wide range of clinical application potential

Abstract This study compared the clinical characteristics of patients with membranous nephropathy (MN) and non-membranous nephropathy (non-MN), and established a non-invasive diagnostic model of MN
.

Included 248 patients with MN and 550 patients with non-MN.

Summary

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Summary

Abstract abstract

This study aimed to compare clinical features between membranous nephropathy (MN) and nonmembranous nephropathy (non-MN), to explore the clinically differential diagnosis of these two types, and to establish a diagnostic model of MN.
After renal biopsy was obtained, 798 patients were divided into two groups based on their examination results: primary MN group (n = 248) and non-MN group (n = 550).
Their data were statistically analyzed.
Logistic regression analysis indicated that anti-PLA2R antibodies, IgG, and Cr were independently correlated with MN, and these three parameters were then used to establish the MN diagnostic model.
A receiver operating characteristic (ROC) curve confirmed that our diagnostic model could distinguish between patients with and without MN, and their corresponding sensitivity, specificity, and AUC were 79.
9%, 89.
4%,and 0.
917, respectively.
The cutoff value for this combination in MN diagnosis was 0.
34.
The established diagnostic model that combined multiple factors shows a potential for broad clinical applications in differentiating primary MN from other kidney diseases and provides reliable evidence supporting the feasibility of noninvasive diagnosis of kidney diseases.

Original information

Textual information textual information

title

title

Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model

Author

Author

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang

mechanism

mechanism

1.
Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing 100853, China

2.
Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing 100853, China

3.
Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Corresponding Authors Yong Wang and Dong Zhang

Corresponding Authors

Cite this article

Cite this article

Hanyu Zhu, Bo Fu, Yong Wang, Jing Gao, Qiuxia Han, Wenjia Geng, Xiaoli Yang, Guangyan Cai, Xiangmei Chen, Dong Zhang.
Comparative analysis of membranous and other nephropathy subtypes and establishment of a diagnostic model.
Front.
Med.
, 2019, 13(5): 618–625 https://doi.
org/10.
1007/s11684-018-0620-5

https://doi.
org/10.
1007/s11684-018-0620-5 https://doi.
org/10.
1007/s11684-018-0620-5

https://journal.
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1007/s11684-018-0620-5

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1007/s11684-018-0620-5 https://journal.
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1007/s11684-018-0620-5

https://link.
springer.
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1007/s11684-018-0620-5

https://link.
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1007/s11684-018-0620-5 https://link.
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1007/s11684-018-0620-5

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