Comparison of the two surgical methods of glioblastoma in the temporal lobe

The range of invasive growth of glioblastoma (GBM) far exceeds the volume shown by MRI imaging;
recent research data show that pre-temporal lobe excision in patients with glioblastoma in the temporal lobe is expanded than the traditional standard for longer progression-free and total survival.
, excision of the front temporal lobe may lead to certain perioperation complications.
Mattias Schneider of Neurosurgery at the University Hospital of Bonn, Germany, and others compared the safety indicators associated with standard surgical removal of glioblastoma of the temporal lobe and excision of the front temporal lobe, and found no significant difference in the effectiveness of the two surgical methods.
published online September 2020 in Journal of Neuro-Oncology.
the study was included in 61 patients with glioblastoma in the temporal lobe between 2012 and 2018.
inclusion criteria: age ≥18 years old; newly diagnosed temporal lobe GBM, lesions ranging from the temporal pole to the back 5-6cm in the non-dominant hemisphere or 4-5cm back from the temporal pole in the dominant hemisphere, including immersion of the sea horse, amygdala, sea horse side back and inner sniffing beam.
front temporal lobe excision range: non-dominant hemisphere from the temporal pole back 5-6cm, the dominant hemisphere from the temporal pole back 4-5cm.
MRI scan within 72 hours of the surgery and did not show that the enhanced lesions could be considered fully cut.
analyzed the incidence of two groups of patient safety indicators (patient safety indicators, PSIs), hospital-acquired conditions (hospital-acquired conditions, HACs), and complications associated with brain surgery (cranial surgery-related complications, CSCs) (Figure 1).
1. An evaluation of the safety of surgery for glioblastoma in the temporal lobe.
61 patients in the study, 41 routine traditional tumor enlargement excisions and 20 excisions of the front temporal lobes.
61 cases, 6 patients had safety indicator events and 2 hospital condition events.
most common safety indicator events and hospital condition events were postoperative hematoma and urinary tract infections, with rates of 5% and 3%, respectively.
incidence of PSIs in the two groups was 12% and 5%, respectively, and there was no significant difference in complications associated with brain surgery between the two groups (p=1.0).
the median survival of patients in the traditional surgical group was 12 months (95% CI, 5-14), while that of patients in the excision group was 23 months (95% CI, 16-33).
The study compared the safety indicators associated with standard surgical excision of glioblastoma and excision of the front temporal lobe, and the results showed no significant difference.
the effect of tumor excision on survival, the authors believe that glioblastoma of the temporal lobe may consider the use of pre-temporal lobe excision.
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