Composition and classification of granulator

The granulator is mainly composed of feeding hopper, cooling system, pressing device, granulator, screen frame, discharging plate, whole granulator system, transmission system, electrical system, etc It is a kind of swing function of rotary drum Wet powder raw materials can be grinded into particles through wire sieve, and it can also be widely used to crush the existing particles There are usually wet granulation, one-step granulation and dry granulation Wet granulation is characterized by saving time and meeting GMP requirements, good mixing effect, high production efficiency, good particle sphericity, good fluidity, easy cleaning and pollution-free, stable content and low energy consumption It is a kind of equipment with many granulating capacity, fast speed, good granulation and low energy consumption, which is popular with users At present, several solid preparation processes account for 70% of all solid preparation granulating equipment However, it has certain requirements for the granulating materials One step granulation (also known as fluidized bed granulation) integrates mixing, granulation and drying The finished granulation products are relatively loose with a particle size of about 40-80 mesh It is characterized by high production efficiency, low labor intensity, low external pollution and neat finished product particles Its disadvantages are high power consumption and different control parameters Dry granulation is to make large pieces of powder mixture by pressing and then crush the whole powder to make the required particle size, which is suitable for wet heat sensitive drugs The dry granulation equipment is characterized by less equipment, small floor area, time-saving and labor-saving At the same time, the tablets are easy to disintegrate because no adhesive is used in granulation The disadvantage is that the "dust escape" is serious and easy to cause cross contamination during tablet pressing, and the dissolution rate of pressed particles is slow, so it is not suitable for water-soluble drugs.