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A team of scientists has developed a method that produces for the first time a genetic amplification and missing visualization, called a single-cell edirate of copy numbers.
notable, this breakthrough in the journal PLoS Biology allows for early detection of rare genetic events, providing high-resolution analysis of the evolutionary rhythm.
method could provide a new way to study mutations in pathogens and human cancers.
"Evolution and disease are driven by mutation events in DNA," explains David Gresham, an associate professor in the Department of Biology at New York University and senior author of the study.
" however, in cell populations, these events are currently unrecognizable until many cells contain the same mutations.
our methods detect these rare events as soon as they occur, allowing us to track the trajectory of populations as they develop.
" the study, led by New York University Ph.D. candidate Stephanie Lauer, included researchers from the Center for Genomics and Systems Biology at New York University and Stanford University.
copy number variants or CNV are a common source of genetic variation and evolutionary adaptation.
however, the dynamics and diversity of CNV in the evolving population are unclear.
in pLoS biology, scientists conducted evolutionary experiments in the lab by exposing cells to stress.
they studied the molecular processes of CNV formation and the dynamics of their production, selection, and maintenance.
this work uses Saccharomyces cerevisiae, a microorganism commonly used in biomedical and genomics research, and a fluorescent gene that monitors gene amplification and deletion in individual cells.
they found that thousands of new CNVs exist in changing populations under different choices.
most of these mutations never became frequent in the population, but a few lucky mutations eventually survived.
researchers point out that the progress of the study suggests that CNV is a major driver of adaptive evolution of evolutionary microbial populations.
this advance provides a new way to study the evolutionary process of disease caused by CNV becoming the basis for resistance in certain pathogens and tumor formation in some cancers.
Source: Thundernet Space.