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Crystallography in the Study of Protein-DNA Interactions

 Last Update: 2020-12-28
 Source: Internet
 Author: User

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Over the past few years, there has been a dramatic increase in the number of protein-
DNA
cocrystal structures solved at atomic resolution (Table 1 ; for reviews
see
[
74
–
76
]). This has allowed a detailed understanding of how specific proteins interact with DNA (e.g., prokaryotic repressors), but has not facilitated the formulation of a common protein-DNA recognition code, which although suggested earlier (
54
), now appears to be too simplistic (
77
). However, some general observations have emerged from these recent protein-DNA crystal structures, some of which are discussed below.

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