Recently, the research team of Liu Xiufan, academician of the Chinese Academy of Engineering and professor of the School of Veterinary Medicine of Yangzhou University, published a paper in "Science in China: Life Sciences" (English version), "New recombinant H10N3 subtype avian influenza virus in East China is highly pathogenic to mammals and can pass air.
Through the systematic analysis of the receptor binding characteristics of this type of strain and the pathogenicity and transmissibility in different animal models, this result is to prevent and control the epidemic of H10N3 virus in poultry and prevent the recurrence of human infections.
"Clue" found during monitoring
"Clue" found during monitoring Studies have shown that about 70% of human diseases come from animals
On June 1, 2021, China notified the world's first case of human infection with H10N3
What is the source of H10N3, how does it cause human infection, and how to prevent it? Wang Xiaoquan, co-corresponding author of the paper and associate professor of the School of Veterinary Medicine of Yangzhou University, introduced that the research team has been relying on the National Laboratory of Avian Influenza Virus (Yangzhou) for a long time to monitor the live poultry market in East China
"We monitor sampling every month and perform genetic sequencing of the avian influenza virus we have isolated
"The H10N3 virus has actually existed for a long time
Through genomic evolution analysis of the avian H10N3 strain, the team found that its HA and NA genes were derived from H10N8 and H7N3, which are prevalent in poultry in Zhejiang area, respectively, and all internal genes were derived from the S genotype H9N2, which is a new recombinant virus
More importantly, they found that the genomes of the avian H10N3 strain and the human H10N3 strain of the first human infection case are highly homologous, that is, there are only small differences in the genome, and they belong to the same type of virus
Because the genome sequence cannot fully reflect the true biological characteristics of the virus strain, in December 2019, Liu Xiufan's research team set out to conduct in-depth research on the avian H10N3 subtype avian influenza virus
Reveal the key characteristics of the virus
Reveal the key characteristics of the virus "Avian influenza viruses are prevalent in poultry.
Studies have found that the new recombinant H10N3 subtype avian influenza virus not only has the ability to bind to poultry cell surface receptors, but also has the ability to bind to human cell surface receptors
"The key to the formation of a pandemic of avian influenza virus is to have the ability to continuously spread among people
Wang Xiaoquan explained that human infections with avian influenza are usually caused by direct contact with live poultry.
To this end, the research team used chicken as an animal model for further analysis
At the same time, the infected poultry did not show obvious clinical symptoms, which caused the virus to not be detected in time, which in turn caused the virus to be prevalent in poultry for a long time
.
Provide strong support for prevention and control
Provide strong support for prevention and control Since the end of 2019, after one year, Liu Xiufan's team will complete the research in December 2020
.
They believe that H10N3 is a new recombinant virus with a strong ability to infect humans and can be spread through the air
.
It is a lethal infection in mammalian models .
This conclusion overturned previous predictions, indicating that H10N3 poses a greater threat to public health security and requires attention
.
How to prevent and control the infection of the new recombinant H10N3 subtype avian influenza virus? Wang Xiaoquan introduced that the avian influenza virus causes human infections mainly due to direct human contact with poisoned poultry, wild birds or their excreta.
"Although the virus has the potential to cause a pandemic in the population, we only need to cut off the'path'.
It can still be avoided
.
"
Wang Xiaoquan suggested that in daily life, everyone should avoid contact with wild birds or entering wild bird habitats, try to minimize or not go to live poultry markets, reduce unnecessary contact with poultry, and pay special attention to avoid contact with sick and dead poultry
.
"Avoiding the hazards of bird flu and not eating poultry meat are two different things.
As long as you purchase fresh poultry meat that has passed inspection and quarantine, you can avoid this threat
.
"
"Animals and humans are a large public health system
.
Only by controlling the source of animal diseases can zoonotic diseases be controlled
.
" Liu Xiufan said that at present, the research team is exploring the cause of a new type of recombinant H10N3 subtype avian influenza virus.
The mechanism of infecting people across species
.
"Although the probability of being infected with avian influenza virus in the exposed population is very low, we must strengthen the monitoring of the avian influenza virus to prevent the virus from mutating and spreading from person to person, triggering a new influenza epidemic
.
Therefore, the control of avian influenza is not only economical.
It is of great significance, and it also plays an important role in public health
.
" Liu Xiufan said
.
(Source: China Science News Li Chen Yulu)
Related paper information: https://doi.
org/10.
1007/s11427-020-1981-5
https://doi.
org/10.
1007/s11427-020-1981-5 https://doi.
org/10.
1007/s11427-020-1981-5
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