Decreased serum UA levels predict the prognosis of TBI patients

Ref: Liu H, et alInt J Med Sci2018 Jun 23;15 (10): 1072-1082doi: 10.7150/ijms.25799eCollection 2018uric acid (UA) is an important antioxidant in the serum and has been considered the main cause of goutRecent studies have confirmed that UA has a neuroprotective effect on patients with ischemic strokeHan Liu of The First Hospital of Chongqing Medical University, who evaluated the clinical effects of UA on the prognosis of TBI patients, and further studied the mechanisms by which UA plays a protective role in traumatic brain injury in animal models, published in the June 2018 issue of the Journal of International Journal of Medicinethe study included 193 TBI patients between May 2013 and December 2016, all measuring serum UA concentrations within 3 days of TBIThe clinical condition at discharge was assessed according to the GOS prognosis scale, with a score of 4-5 for good prognosis and a score of 1-3 as a poor prognosisThe correlation between serum UA concentration and clinical results was analyzed by logistic regression modelIn animal experiments, a brain injury model was created for controlled impact mice cortex (c.C90 male C57BL/6 mice, aged 25-30g, were randomly divided into fake surgical groups (n-16), physiological saline groups (n-31), UA1 groups (n-31), UA2 groups (n-6) and UA3 groups (n-6)The UA is heated and dissolved in physiological saline and cooled at room temperature after being adjusted by NaOH and HCl to pH 7-8 solutionThe TBI model of mice was made from day 1 to 14, with three different doses of UA solution injected into the abdominal cavity: 16 mg/kg in the UA1 group; UA levels in serum and brain tissue in mice were measured, and changes in neurofunction, oxidative stress of brain tissue, inflammatory response, neuronal repair, cerebral blood flow and lesions were assessed in miceclinically, the serum UA level of patients with good TBI prognosis decreased significantly (P 0.01), and the low serum UA content was a good independent predictor of TBI prognosis (OR-0.023; 95% CI, 0.006-0.082; P.01)Serum UA level decreased on average in TBI patients and experimental animals (P 0.05), while the concentration of UA was increased in brain tissue in laboratory mice (P 0.05)Compared to the mice in the control group, it was shown that uA was given to further increase the UA content of brain tissue in mice (P 0.05)In different doses of experimental mice, 16 mg/kg of UA improved animal sensation and motor function, spatial learning and memory recovery (P 0.05)In addition, UA treatment inhibits oxidative stress and inflammatory response in brain tissue (P 0.05)UA treatment also repairs neurons and increases cortical blood flow (P 0.05), but does not change the size of the lesions (P 0.05)the study showed that UA reduced brain tissue damage, increased brain perfusion and improved nerve function in TBI mice by inhibiting neuronoxidation stress and vascular oxidative stress responseActive antioxidant defenses in the brain after TBI may consume UA in the serumTherefore, the decrease in serum UA content indicates clinical recovery(
Xiaoxincompiled by The Sun, Director-General of "Outside Information" and Professor Chen ChengchengChen Yucheng, Affiliated with Fudan University)related links