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    Home > Biochemistry News > Microbiology News > Dendritic Cell Generation from Highly Purified CD14+Monocytes

    Dendritic Cell Generation from Highly Purified CD14+Monocytes

    • Last Update: 2021-02-15
    • Source: Internet
    • Author: User
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    Dendritic cells (DC) play a pivotal role in the function of the immune system, for they are the primary antigen-presenting cells (APC) in the activation of naive T-lymphocyte responses (
    1
    ). Recent studies have uncovered complexity in the DC lineage with several subsets, functions, and maturational stages. Although it is generally accepted that human DC derive from hematopoietic progenitor cells (
    2
    -
    9
    ), it is not clear at present whether DC cells and their precursors represent a separate hematopoietic lineage or whether DC should be seen as specialized macrophages with particular morphological, molecular, and functional features. Several lines of evidence point to DC and monocytes/ macrophages being offspring of the same CD34
    +
    hematopoietic progenitor cell (
    3
    -5 ,12 -
    14
    , and reviewed in ([
    10
    ,11 ].) DC committed precursor cells have also been identified in peripheral blood (
    15
    -
    18
    ).
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