Design and Construction of Poliovirus Epitope Expression Vectors
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Last Update: 2021-02-22
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Source: Internet
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Author: User
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We have developed the very safe and efficacious live-attenuated Sabin 1 poliovirus vaccine strain as a vehicle for the presentation of defined epitopes from foreign pathogens (
1
–
3
). Precise modification of the poliovirus capsid is made possible by the application of recombinant
DNA
technology to cloned
cDNA
copies of the viral genome, which are infectious for mammalian cells in culture (
4
).
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