Detection of gene polymorphism

polymorphism" refers to a group in which there are more than 2 genotypes in the same -bit. In the population, there are differences in the >nucleotides sequences of individual genes called gene (DNA) polymorphism. This polymorphism can be divided into two categories, namely DNA site polymorphism and longth polymorphism.detection methods for gene polymorphism are as follows:

9. < a href": > gene chip : also known as a DNA micro-probe array. It is a large number of dense arrangement of a large number of known sequence probes, by matching with a number of marked target"> nucleic acid" sequence complement each other, with the chip on a specific point of probe hybridization, the use of gene chip hybrid image, determine the location of hybrid probe, according to the principle of base complementary matching can determine the sequence of the target gene. This technique has been used for the detection of gene polymorphism. The multi-color fluorescent probe hybridization technology for polymorphic and mutation detection gene chips can greatly improve the accuracy, quantification and detection range of the chip. The application of high density gene chip to detect single base polymorphism provides a convenient method for analyzing SNPs. 10. The AFLP Method